Results 331 to 340 of about 256,874 (388)

Mitochondrial fission protein 1 in the regulation of mitochondrial quality control: A cancer perspective

Interdisciplinary Medicine, EarlyView.
Background: Mitochondrial fission protein (FIS1), affecting energy metabolism and homeostasis, is crucial for mitochondrial quality control (MQC) and tumor progression. Key Points: It varies in expression across TME, influencing tumor progression.
Chao Wei, Xiaoling Yuan, Xiaoli Liu, Jia Feng, Miao Song, Xuexue Liu, Jiahong Zhou, Jinbo Liu   +7 more
wiley   +1 more source

Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction-Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransferase-Mediated Nicotinamide Dinucleotide Levels. [PDF]

J Am Heart Assoc
Habeichi NJ, Amin G, Boitard S, Tannous C, Ghali R, Momken I, Diab R, Booz GW, Mericskay M, Zouein FA.   +9 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice. [PDF]

Sci Adv
Xie Y, Zhou C, Guo Q, Guo Y, Guo J, Chen L, Liu X, Zeng Y, Liang Q, Wu T, Liu J, Liang X.   +11 more
europepmc   +1 more source

Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in <i>db/db</i> Mice. [PDF]

Metabolites
Shirouchi B, Mitsuta S, Higuchi M, Okumura M, Tanaka K.   +4 more
europepmc   +1 more source

Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation. [PDF]

BMC Chem
Hamoud MMS, Ghanim AM, Hassan AEA, Abdel-Fattah HA, Abbas HA, Seleem NM, Kothayer H, Osman NA.   +7 more
europepmc   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial. [PDF]

Aging Cell
Shoji M, Kato H, Koshizaka M, Kaneko H, Baba Y, Ishikawa T, Teramoto N, Kinoshita D, Yamaguchi A, Maeda Y, Inaba Y, Shiko Y, Ozawa Y, Bohr VA, Maezawa Y, Yokote K.   +15 more
europepmc   +1 more source

Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models. [PDF]

Sci Rep
Curran CS, Cui X, Li Y, Gamble T, Sun J, Minkove S, Livinski AA, Eichacker PQ, Torabi-Parizi P.   +8 more
europepmc   +1 more source

New nicotinamide-thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and <i>in silico</i> and <i>in vitro</i> evaluation. [PDF]

RSC Adv
Elgammal WE, Elkady H, Yousef RG, Eldehna WM, Husein DZ, Amin FG, Alsfouk BA, Elkaeed EB, Eissa IH, Metwaly AM.   +9 more
europepmc   +1 more source