Results 301 to 310 of about 140,109 (356)
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Nicotinic Acetylcholine Receptor Assays
Current Protocols in Pharmacology, 1999AbstractNicotinic acetylcholine receptors (nAChRs) in peripheral tissues are localized almost exclusively to autonomic nerves and the motor end plates of striated musculature. Pharmacologic analyses of nicotinic receptor antagonist potencies can be conducted by assessing the ability of these compounds to inhibit responses elicited by preganglionic ...
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Nicotinic Acetylcholine Receptors and Imaging
Current Pharmaceutical Design, 2000In vivo imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer the possibility to monitor human central nicotinic acetylcholine receptors (nAChRs) in a variety of central nervous system disorders. In the past, the only available PET radiotracer for imaging nAChRs in the human brain, [11C]-
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The diversity of neuronal nicotinic acetylcholine receptors.
Annual Review of Neuroscience, 1993P. Sargent
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Steroids inhibit nicotinic acetylcholine receptors
NeuroReport, 1991Application of progesterone to Xenopus oocytes expressing a cloned neuronal nicotinic acetylcholine (nAChR) revealed two effects. The first effect was a fully reversible reduction of the current induced by acetylcholine (ACh), its onset being nearly instantaneous. The second effect, which developed in a few hours, was an irreversible suppression of ACh-
Bertrand, Daniel +4 more
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The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease
Nature Reviews Neurology, 2023I. Fontana, Amit Kumar, A. Nordberg
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Neuronal Nicotinic Acetylcholine Receptors
1996Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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α7 nicotinic acetylcholine receptors in Alzheimer's disease: neuroprotective, neurotrophic or both?
Current Drug Targets, 2012One of the early signs of Alzheimer's disease is the impairment in hippocampus-based episodic memory function, which is improved through the enhancement of cholinergic transmission.
C. Hernandez, K. Dineley
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Inhibition of nicotinic acetylcholine receptors by bicuculline
Neuropharmacology, 2001A study was made on the effects of bicuculline, the classical gamma-aminobutyric acid-A receptor antagonist, on heteromeric mouse muscle alphabetagammadelta, heteromeric neuronal rat alpha2beta4 and alpha4beta2 and homomeric human alpha7 nicotinic acetylcholine receptors (nAChRs), expressed in Xenopus oocytes.
Fabrizio Eusebi +3 more
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Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons.
Annual Review of Physiology, 1995The last decade has revealed an astounding degree of physiological and st ruct ural divers it y in neurot ransmitteract ivated receptors. In part icular, mo lecular st udies of the acet ylcholine-gated recept ors in vert ebrate muscle cells and Torpedo ...
D. McGehee, L. Role
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Nicotinic Acetylcholine Receptors and Anesthetics
2003Nicotinic acetylcholine receptors (nAChRs) are a diverse group of membrane proteins found in many types of excitable tissue, including brain, autonomic ganglia, and muscle. Acetylcholine (ACh), the endogenous ligand for these receptors, binds to agonist sites on nAChRs, causing opening of an intrinsic transmembrane cation channel and depolarization of ...
Stuart A. Forman +2 more
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