Results 181 to 190 of about 97,079 (192)

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia   +3 more
wiley   +1 more source

LC‐IRMS Persulfate Oxidation: Case Study on Neonicotinoid‐Related Structures

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue 16, 30 August 2025.
ABSTRACT Rationale Liquid chromatography‐isotope ratio mass spectrometry (LC‐IRMS) is used to analyze stable carbon isotope ratios of polar nonvolatile compounds. However, challenges with the persulfate‐based oxidation interface have been reported, particularly for molecules with recalcitrant structures like those found in neonicotinoids.
Felix Niemann   +3 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain   +6 more
wiley   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

open access: yesAdvanced Functional Materials, Volume 35, Issue 23, June 5, 2025.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong   +7 more
wiley   +1 more source

Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry in recent years. Enabling the direct analysis of samples in their native state with neither sample preparation nor chromatographic separation provides chemical characterisation in a matter of seconds.
Alisha Henderson   +2 more
wiley   +1 more source

Release Monitoring and Detection of Formulated Solid Nanoparticle–Conjugated Nicotine in Blood and Urine Using Electrochemical Technique

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Tobacco (nicotine) has been reported as one of the worst global public health pandemics in history, claiming about 8 million lives annually. According to the World Health Organisation (WHO), nicotine accounts for about 7 million deaths of firsthand users and over 1.3 million morbidities of secondhand users.
Blessing Wisdom Ike   +8 more
wiley   +1 more source

GABRP Mediates GABA‐A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy

open access: yesCancer Medicine, Volume 14, Issue 11, June 2025.
Beyond its well‐established role in suppressing neuronal excitability, GABA (γ‐aminobutyric acid) has been shown to inhibit immune cell functions. Cancer cells exploit GABA signaling to modulate the tumor microenvironment and impair normal immune cell activities, thereby facilitating immune evasion.
Wu Cen   +9 more
wiley   +1 more source

Medication Purchases Are Associated With the Number of Dental Treatments

open access: yesClinical and Experimental Dental Research, Volume 11, Issue 3, June 2025.
ABSTRACT Objectives Little is known whether the number of systemic medications, indicating worsened general health, affects the number of dental appointments needed. The hypothesis is that patients purchasing more systemic medications would have an increased number of dental appointments and respective need for treatments than patients who do not ...
Freja Frankenhaeuser   +4 more
wiley   +1 more source

Neural Electrical Correlates of Subjective Happiness

open access: yesHuman Brain Mapping, Volume 46, Issue 8, June 1, 2025.
We investigated neural electrical correlates of subjective happiness by analyzing resting‐state magnetoencephalography and measures of subjective happiness. Gamma‐band lower spontaneous neural fluctuation values in the right precuneus were associated with higher subjective happiness scores.
Wataru Sato   +2 more
wiley   +1 more source

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