Results 61 to 70 of about 143,741 (208)
α1-Y233 and α1-Y275 mutants enhance the potency of nicotinic receptor agonists.
, 2016 α1-Y233 and α1-Y275 mutants enhance the potency of nicotinic receptor agonists.
Edward J. Oakeley (9999) +13 more
core +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Nature CommunicationsEpilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen +13 more
doaj +1 more source
Pharmacological Research, 2023 Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated
Arik J. Hone, J. Michael McIntosh
doaj +1 more source
Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]
, 2002 Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core
Clinical Pharmacology &Therapeutics, EarlyView.Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai +12 more
wiley +1 more source
Anion Conducting States of Excitatory Amino Acid Transporters [PDF]
, 2013 Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which translocate L-glutamate (glu) against its concentration gradient using the co-transport of 3 Na+, 1 H+, and the counter-transport of 1 K+ ion.
Divito, Christopher B.
core
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning +2 more
wiley +1 more source
Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors
Anais da Academia Brasileira de Ciências, 2002 Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be ...
TORRÃO ANDRÉA S., BRITTO LUIZ R.G.
doaj
Inhaled corticosteroids versus long-acting beta2-agonists for chronic obstructive pulmonary disease [PDF]
, 2011 Background Long-acting beta2-agonists and inhaled corticosteroids can be used as maintenance therapy by patients with moderate to severe chronic obstructive pulmonary disease. These interventions are often taken together in a combination inhaler. However,
David J Evans +12 more
core +1 more source