Results 101 to 110 of about 12,273 (193)

Decreased NPC1L1 expression in the liver from Chinese female gallstone patients [PDF]

, 2010
Background Cholesterol gallstone disease is a very common disease in both industrialized and developing countries. Many studies have found that cholesterol gallstones are more common in women than men. The molecular mechanisms underlying the relationship
Wei Cui, Zhao-Yan Jiang, Qu Cai, Ru-Yuan Zhang, Wei-Ze Wu, Jian-Cheng Wang, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han   +8 more
core   +2 more sources

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system

Microbiology Spectrum
Dehong virus (DEHV) is an emerging filamentous virus of considerable interest. However, research involving DEHV remains limited, and no suitable models exist to investigate its pathogenicity or transmission.
Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang   +13 more
doaj   +1 more source

Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease.

PLoS ONE, 2017
In vivo magnetic resonance imaging (MRI) was used to investigate regional and global brain atrophy in the neurodegenerative Niemann Pick Type C1 (NPC1) disease mouse model.
John W Totenhagen, Adam Bernstein, Eriko S Yoshimaru, Robert P Erickson, Theodore P Trouard   +4 more
doaj   +1 more source

Increased Regenerative Capacity of the Olfactory Epithelium in Niemann-Pick Disease Type C1. [PDF]

Int J Mol Sci, 2017
Niemann–Pick disease type C1 (NPC1) is a fatal neurovisceral lysosomal lipid storage disorder. The mutation of the NPC1 protein affects the homeostasis and transport of cholesterol and glycosphingolipids from late endosomes/lysosomes to the endoplasmic reticulum resulting in progressive neurodegeneration.
Meyer A, Wree A, Günther R, Holzmann C, Schmitt O, Rolfs A, Witt M.   +6 more
europepmc   +4 more sources

Oligodendroglial Process Formation is Differentially Affected by Modulating the Intra- and Extracellular Cholesterol Content [PDF]

, 2012
Cholesterol is an essential component of eukaryotic plasma membranes and plays an important role in membrane organization and signaling processes. It is the major lipid component of detergent resistant caveolin-1 containing rafts which previously had ...
Hans H. Althaus, Inga Zerr, Matthias Schmitz, Sandra C. Signore   +3 more
core   +1 more source

Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology

BioFactors, Volume 52, Issue 1, January/February 2026.
This review delves into bioinspired olfactory biosensors, focusing on insect odorant binding proteins (OBPs) as core elements of hybrid bionic platforms for volatile compound detection. Highlighting the development of the biological electronic nose (BE‐NOSE), it examines current prototypes, outlines advantages over conventional methods, and explores ...
Maddalena Ventura, Miriam Viola, Krishna C. Persaud, Antonio Guerrieri, Carmen Scieuzo, Patrizia Falabella   +5 more
wiley   +1 more source

Targeting Molecular Chaperone HSP90 To Treat Niemann‐Pick Type C1 Disease

The FASEB Journal, 2019
NPC1 is a fatal, neurodegenerative lysosomal storage disease caused by mutations in the NPC1 gene. More than 300 different disease‐associated mutations are reported in patients, resulting in abnormal accumulation of unesterified cholesterol, glycosphingolipids and other lipids in late ...
Nina H Pipalia, Kangaraj Subramanian, Abigail Cross, Kunal Garg, Aisha Al‐Motawa, Frederick R Maxfield   +5 more
openaire   +1 more source

Uncovering the Causal Link Between Obesity‐Associated Genes and Multiple Sclerosis: A Systematic Literature Review

Brain and Behavior
Background: Multiple sclerosis (MS) is a multifaceted neurodegenerative disorder influenced by genetics and lifestyle. This systematic literature review investigates the role of six obesity‐associated genes, including fat mass and obesity‐associated (FTO)
Ali Jafari, Sara Khoshdooz, Melika Arab Bafrani, Farnush Bakhshimoghaddam, Hamid Abbasi, Saeid Doaei   +5 more
doaj   +1 more source

Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. [PDF]

, 2019
To understand the impact of epigenetics on human misfolding disease, we apply Gaussian-process regression (GPR) based machine learning (ML) (GPR-ML) through variation spatial profiling (VSP). VSP generates population-based matrices describing the spatial
Balch, William E, Farhat, Nicole Y, Hutt, Darren M, Loguercio, Salvatore, Porter, Forbes D, Scott, Samantha M, Subramanian, Kanagaraj, Wang, Chao, Zhao, Pei   +8 more
core   +1 more source