Results 131 to 140 of about 53,089 (317)

Inheritance of nipple numbers in swine and the relationship to performance [PDF]

open access: yes, 1959
This bulletin is a report of research under Project 3, 'Improvement of swine through breeding,' Department of Animal Husbandry in cooperation with the Regional Swine Breeding Laboratory, A.H.R.D., A.R.S., U.S. Department of Agriculture--P.
Allen, A. D.   +2 more
core  

Fabrication of Multimodal Anion Exchange Membrane for Chromatographic Purification of Full Adeno‐Associated Viral Capsids

open access: yesAdvanced Materials Interfaces, EarlyView.
A novel multi‐modal anion exchange membrane (MMAEX) is successfully fabricated for separating empty and full AAV2 capsids. The functionalized membrane has an average pore size of 0.5 µm and exhibits both charge and hydrophobic functionality. A full capsid recovery of 72.9% at 85.3% purity with gradient elution, or 70.3% recovery at 92.2% purity with ...
Xiaolei Hao   +2 more
wiley   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

open access: yesAdvanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack   +13 more
wiley   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

open access: yesAdvanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong   +16 more
wiley   +1 more source

\u27Art\u27 They Can\u27t See, Lines, Anatomy of Decomposing, October on Danford Creek, Wing Bone, and Taxidermy [PDF]

open access: yes, 2019
The following document includes a selection and submission for the Hilltop Review. Within the file the reader will find five (5) poems and one (1) micro fiction piece.
Dekker, Kailyn J
core   +1 more source

AN IMPROVED NIPPLE-SHIELD. [PDF]

open access: green, 1906
J. Morris Slemons
openalex   +1 more source

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

open access: yesAdvanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai   +19 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

open access: yesAdvanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li   +13 more
wiley   +1 more source

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