Results 161 to 170 of about 76,730 (376)
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science, EarlyView.This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang +9 more
wiley +1 more source
NURSING IN MISSION STATIONS A CASE OF DEPRESSED NIPPLES WITH OCCLUDED DUCTS [PDF]
, 1915 Jennie Manget Logan
openalex +1 more source
Advanced Science, EarlyView.Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han +24 more
wiley +1 more source
Atrophic scirrhus of one mammary gland associated with Paget's disease of the nipple on the opposite side [PDF]
, 1904 openalex +1 more source
Microgravity: a Teacher's Guide with Activities, Secondary Level [PDF]
, 1992 This NASA Educational Publication is a teacher's guide that focuses on microgravity for the secondary level student. The introduction answers the question 'What is microgravity?', as well as describing gravity and creating microgravity.
Vogt, Gregory L., Wargo, Michael J.
core +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
On the Diagnostic Value of the Retracted Nipple as a Symptom of Disease of the Breast [PDF]
Thomas Bryant
openalex +1 more source