Results 171 to 180 of about 76,730 (376)

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

open access: yesAdvanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang   +8 more
wiley   +1 more source

Determinants of Neonatal and Post-neonatal Mortality in Pakistan [PDF]

open access: yes
Ensuring the survival and well being of children is a concern of families, communities and nations throughout the world. Since the turn of the 20th century infant and child mortality in more developed countries has steadily declined and, currently, has ...
M. Arshad Mahmood
core  

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

open access: yesAdvanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu   +17 more
wiley   +1 more source

Valve, normally closed, titanium Pyronetics model 1426 [PDF]

open access: yes
Performance tests of the explosive actuated, normally closed titanium valve 1426, are outlined. The valves are used to control hydrazine flow in a monopropellant thruster. Data cover pressure tests, internal and external leakage tests, flow control tests,
Avalos, E.
core   +1 more source

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

open access: yesAdvanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu   +7 more
wiley   +1 more source

Chin-spot as an indicator of age in pond bats [PDF]

open access: yes
Tijdens ecologisch veldonderzoek is het vaak nuttig om de leeftijd van een dier te kunnen bepalen. Bij de watervleermuis (Myotis daubentonii) kan de verkleuring van de kinvlek gebruikt worden om de leeftijd van het individu te bepalen.
Alphen, J., van, Haarsma, A.J.
core   +2 more sources

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs

open access: yesAdvanced Science, EarlyView.
Ubiquitin‐mediated selective autophagy plays a critical role in antiviral innate immunity. The study shows that upon RNA virus infection, cytoplasmic API5 undergoes SRPK1‐dependent phosphorylation at S464, which in turn suppresses p62 K141 ubiquitination‐dependent autophagy.
Tingjuan Deng   +10 more
wiley   +1 more source

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