Results 41 to 50 of about 155,363 (336)

Sirtuin Oxidative Post-translational Modifications

Frontiers in Physiology, 2021
Increased sirtuin deacylase activity is correlated with increased lifespan and healthspan in eukaryotes. Conversely, decreased sirtuin deacylase activity is correlated with increased susceptibility to aging-related diseases.
Kelsey S. Kalous, Sarah L. Wynia-Smith, Brian C. Smith   +2 more
doaj   +1 more source

A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications [PDF]

, 2019
A photocurable and viscous fluoropolymer with chemical stability is a highly desirable material for fabrication of microchemical devices. Lack of a reliable fabrication method, however, limits actual applications for organic reactions.
Im, DJ, Kim, DP, Kim, H, Kim, JO, Ko, DH, Min, KI, Park, SY   +6 more
core   +1 more source

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

ANSID: a Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites

Frontiers in Chemistry, 2016
Nitration of tyrosine and other aromatic amino acid residues in proteins occurs in the setting of inflammatory, neurodegenerative and cardiovascular diseases – importantly, this modification has been implicated in the pathogenesis of diverse diseases and
Tal eNuriel, Tal eNuriel, Julia eWhitehouse, Yuliang eMa, Emily eMercer, Emily eMercer, Neil eBrown, Steven S Gross   +7 more
doaj   +1 more source

High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells

Antioxidants, 2018
Diabetes and hyperglycemia are associated with increased retinal oxidative and nitrative stress and vascular cell death. Paradoxically, high glucose stimulates expression of survival and angiogenic growth factors.
Sally L. Elshaer, Tahira Lemtalsi, Azza B. El-Remessy   +2 more
doaj   +1 more source

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation

Redox Biology
Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that tyrosine nitration supports schwannoma cell proliferation and regulates cell metabolism in the inheritable ...
Isabelle E. Logan, Kyle T. Nguyen, Tilottama Chatterjee, Bhagyashree Manivannan, Ngozi P. Paul, Sharon R. Kim, Evelyn M. Sixta, Lydia P. Bastian, Carrie Marean-Reardon, Matthias A. Karajannis, Cristina Fernández-Valle, Alvaro G. Estevez, Maria Clara Franco   +12 more
doaj   +1 more source

Laboratory‐Scale Procedure for Evaluating the Flux Efficiency on Melt Cleanliness and Tensile Properties of Recycled Aluminum Alloys

Advanced Engineering Materials, EarlyView.
A laboratory‐scale procedure is developed to evaluate the efficiency of melt‐cleaning and drossing fluxes during aluminium alloy recycling, studying their effects on melt cleanliness and tensile properties of secondary foundry alloys. This work provides a practical tool for foundries and aluminium refiners to assess the efficiency of salt fluxes in ...
Veronica Milani, Giulio Timelli
wiley   +1 more source

Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration

Scientific Reports, 2017
Nitroaromatics are among the most important and commonly used chemicals but their production often suffers from multiple unsolved challenges. We have previously described the development of biocatalytic nitration processes driven by an engineered P450 ...
Ran Zuo, Yi Zhang, Chao Jiang, John C. Hackett, Rosemary Loria, Steven D. Bruner, Yousong Ding   +6 more
doaj   +1 more source