Results 41 to 50 of about 432,709 (333)

SYNTHESIS OF 6-NITRO VERATRYL ALCOHOL AND 6-NITRO VERATRALDOXIM FROM VANILIN AS INTERMEDIATES FOR THE PREPARATION OF C-9154 ANTIBIOTIC DERVATIVES

open access: yesIndonesian Journal of Chemistry, 2010
The synthesis of 6-nitro veratryl alcohol and 6-nitro veratraldoxim from vanilin which was required as intermediates for the preparation of C-9154 antibiotic derivatives was carried out.
Jumina Jumina   +2 more
doaj   +1 more source

Genetically encoded fluorescent redox probes. [PDF]

open access: yes, 2013
Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling.
Ai, Hui-Wang, Ren, Wei
core   +3 more sources

Acetonyltriphenylphosphonium nitrate [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2013
Crystals of the title salt, C21H20OP+·NO3−, are composed of acetonyltriphenylphosphonium cations and nitrate anions that mainly interact through electrostatic forces. The P atom in the cation has a slightly distorted tetrahedral environment, with C—P—C angles ranging from 104.79 (7) to 112.59 (6)°. The sum of O—N—O angles of the nitrate anion is 359.99°
Tidiane Diop   +3 more
openaire   +3 more sources

A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications [PDF]

open access: yes, 2019
A photocurable and viscous fluoropolymer with chemical stability is a highly desirable material for fabrication of microchemical devices. Lack of a reliable fabrication method, however, limits actual applications for organic reactions.
Im, DJ   +6 more
core   +1 more source

Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.

open access: yesArchives of Biochemistry and Biophysics, 1998
Analytical and immunological methodologies and occasionally both methodologies have been applied to detect and quantify 3-nitrotyrosine in almost every major organ system.
H. Ischiropoulos
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation

open access: yesRedox Biology
Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that tyrosine nitration supports schwannoma cell proliferation and regulates cell metabolism in the inheritable ...
Isabelle E. Logan   +12 more
doaj   +1 more source

Sirtuin Oxidative Post-translational Modifications

open access: yesFrontiers in Physiology, 2021
Increased sirtuin deacylase activity is correlated with increased lifespan and healthspan in eukaryotes. Conversely, decreased sirtuin deacylase activity is correlated with increased susceptibility to aging-related diseases.
Kelsey S. Kalous   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration

open access: yesScientific Reports, 2017
Nitroaromatics are among the most important and commonly used chemicals but their production often suffers from multiple unsolved challenges. We have previously described the development of biocatalytic nitration processes driven by an engineered P450 ...
Ran Zuo   +6 more
doaj   +1 more source

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