Results 281 to 290 of about 584,174 (352)
XLI.—On Nitric Acid as a Source of the Nitrogen found in Plants [PDF]
George Wilson
openalex +1 more source
Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo+10 more
wiley +1 more source
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei+11 more
wiley +1 more source
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin+6 more
wiley +1 more source
Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou+13 more
wiley +1 more source
Fe@WO3/ZnCo2O4 n‐p heterojunction sensor exhibits excellent room‐temperature sensing toward tetradecane, with a low detection limit of 78.4 ppb and short recovery time. The good performance is attributed to synergistic effects from heterojunctions, heteroatom doping, oxygen vacancies, high‐energy facets, and theoretical validations.
Kewei Liu+5 more
wiley +1 more source
Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen+7 more
wiley +1 more source