Results 301 to 310 of about 963,417 (364)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

open access: yesAdvanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu   +16 more
wiley   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

open access: yesAdvanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi   +12 more
wiley   +1 more source

From Prognostic Marker to Therapeutic Agent: The Role of Nitric Oxide in Lung Cancer. [PDF]

open access: yesJ Clin Med
Pianigiani T   +6 more
europepmc   +1 more source

Phytohormone Response to Exogenous Nitric Oxide in Cucumber Under Low-Temperature Stress. [PDF]

open access: yesPlants (Basel)
Wu P   +8 more
europepmc   +1 more source

A Refined Carbohydrate-Rich Diet Reduces Vascular Reactivity Through Endothelial Oxidative Stress and Increased Nitric Oxide: The Involvement of Inducible Nitric Oxide Synthase. [PDF]

open access: yesNutrients
Neumann K   +10 more
europepmc   +1 more source

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