Results 341 to 350 of about 361,848 (377)

Mitochondrial nitric oxide synthase

Mitochondrion, 2004
Nitric oxide (NO*) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory chain, cytochrome c oxidase (complex IV). In vivo, NO* is made by the NO* synthase (NOS) family of enzymes, and considerable debate has recently arisen regarding a NOS inside mitochondria (termed 'mtNOS').
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Mitochondrial nitric oxide synthase

Frontiers in Bioscience, 2007
Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial
Pedram, Ghafourifar, Chandan K, Sen
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Nitric Oxide Synthase Assays

Current Protocols in Pharmacology, 1998
AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
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Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

Journal of Neuroscience Research, 1997
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa iNOS protein by Western blot analysis; protein was ...
Jean E. Merrill, Allan MacKenzie-Graham, Minzhen Ding, Sean Murphy, Branislava Mitrovic, Joel C. Dopp, Louis J. Ignarro, Charles J. Lowenstein, Jeannette Griscavage   +8 more
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Nitric Oxide and Nitric Oxide Synthase Inhibitors in Sepsis

Digestive Surgery, 1996
Nitric oxide (NO) is a simple but biologically highly active gas. It has multiple roles in normal physiology, e.g. as a potent vasodilator, immunomodulator and neurotransmitter.
Hans Ulrich Rothen, Daniel Schölly
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Nitric oxide, nitric oxide synthase, and hypertensive vascular disease

Current Hypertension Reports, 1999
In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and the vasodilator and growth inhibitory influence predominates. Hypertension, however, is associated with a shift towards enhanced constriction and vascular hypertrophy.
Rudi Busse, Ingrid Fleming
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Nitric Oxide Synthase Expression and Nitric Oxide Toxicity in Oligodendrocytes

Antioxidants & Redox Signaling, 2006
Oligodendrocytes (OLG) have more complex interactions with nitric oxide (NO) than initially suspected. Historically, OLG were seen only as targets of high NO levels released from other cells. Expression of nitric oxide synthase type II (NOS-2) in primary cultures of OLGs stimulated by cytokines led to controversy due to the presence of small numbers of
Joyce A. Benjamins, Anne I. Boullerne
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mRNA Expressions of Inducible Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase, and Neuronal Nitric Oxide Synthase Genes in Meningitis Patients

Genetic Testing and Molecular Biomarkers, 2011
Meningitis is an inflammation of the protective membranes covering the brain and spinal cord caused by bacteria, fungi, or viruses with various clinical symptoms. Although meningitis is not so prevalent, it remains the most serious contagious disease. The aim of our study was to investigate the effect of gene expressions of nitric oxide synthases (NOS)
Ahmet Arslan, Mehmet Yavuz Coskun, Bulent Gogebakan, Yusuf Ziya Igci, Ecir Ali Çakmak, Ercan Sivasli, Mehri Igci, Seniz Demiryürek, Mustafa Namiduru, Beyhan Cengiz, Serdar Oztuzcu, Esma Ozkara   +11 more
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[25] Nitric-oxide synthase assays

1994
Publisher Summary This chapter provides an overview of nitric-oxide synthase assays. Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to form citrulline and nitric oxide (.NO). The physiological involvement of .NO in neuronal transmission, control of vascular tone, and immune response-induced cytostasis and the deleterious effects ...
Michael A. Marletta, Joan M. Hevel
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Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis

Current Atherosclerosis Reports, 2004
There is a complex pathophysiologic scenario involving nitric oxide (NO), endothelial nitric oxide synthase (eNOS), and the development of atherosclerosis and unstable atheroma. Endothelial damage induced by atherosclerosis leads to the reduction in bioactivity of eNOS with subsequent impaired release of NO.
Claudio Napoli, Louis J. Ignarro
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