Results 141 to 150 of about 136,976 (295)
Promising Prodiginins Biological Activities
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto+6 more
wiley +1 more source
Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi+7 more
wiley +1 more source
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves+3 more
wiley +1 more source
A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai+4 more
wiley +1 more source
Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review
PRISMA study flow diagram. ABSTRACT Background Elevated high blood pressure is controlled by complicated, little‐understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure‐related genomic loci have been identified through previous genome‐wide association
Lilik Sukesi+7 more
wiley +1 more source
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia+2 more
wiley +1 more source
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem+13 more
wiley +1 more source
Pathophysiologic correlates of exercise intolerance in adults with pulmonary hypertension and congenital heart disease [PDF]
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Diller , Gerhard-Paul+1 more
core
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard+29 more
wiley +1 more source
Objective: This study aimed to explore the cumulative effects and expression patterns of electroacupuncture (EA) on irisin secretion, observe the effects of EA on the recovery of neurobehavioral function and vascular remodeling after cerebral ischemia ...
Lu Cao+15 more
doaj