Results 271 to 280 of about 2,975,483 (362)

Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide. [PDF]

Molecules
Wu YJ, Ma C, Bilal M, Liang YF.
europepmc   +1 more source

Contemporary Strategies in SmI2 Catalysis: A Reagent Reborn

Angewandte Chemie, EarlyView.
The rich chemistry of the single electron transfer reagent SmI2 has been widely exploited in synthesis. Recent years have seen significant progress in SmI2‐catalysis, with provision of a suite of systems that may evolve to provide the efficiency, practicality, and generality needed for widespread adoption. This minireview provides a critical evaluation
Jack I. Mansell, Ciro Romano, David J. Procter   +2 more
wiley   +1 more source

Organo NHC catalyzed aqueous synthesis of 4β-isoxazole-podophyllotoxins: in vitro anticancer, caspase activation, tubulin polymerization inhibition and molecular docking studies. [PDF]

RSC Adv
Nagavath R, Thupurani MK, Badithapuram V, Manchal R, Vasam CS, Thirukovela NS.   +5 more
europepmc   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Analysis of the Reactivity of Z-2-Ar-1-EWG-1-Nitroethene Molecular Segment in the Hetero Diels-Alder Reaction: Experimental and MEDT Quantum Chemical Study. [PDF]

Molecules
Woliński P, Kącka-Zych A, Wielgus E, Dolot R, Jasiński R.   +4 more
europepmc   +1 more source

[3+2] Cycloaddition to a Chiral 5-Methylene-1,3-dioxolan-4-one and Pyrolysis of the Spiro Adducts. [PDF]

Molecules
Aitken RA, Power LA, Slawin AMZ.
europepmc   +1 more source

Photocatalytic Generation of a Ground-State Electron Donor Through Water Activation. [PDF]

Angew Chem Int Ed Engl
Wiethoff MA, Lezius L, Studer A.
europepmc   +1 more source

Energetic Aspects and Molecular Mechanism of 3-Nitro-substituted 2-Isoxazolines Formation via Nitrile N-Oxide [3+2] Cycloaddition: An MEDT Computational Study. [PDF]

Molecules
Dresler E, Wróblewska A, Jasiński R.
europepmc   +1 more source