Results 181 to 190 of about 356,905 (299)

Predicting Drop‐Weight Impact Sensitivity From Molecular Graphs Using Physics‐Informed Artificial Intelligence

Propellants, Explosives, Pyrotechnics, EarlyView.
This work presents an approach for predicting the drop‐weight impact sensitivity of pure molecular explosives directly from 2D molecular graphs using physics‐informed artificial intelligence (AI) models. A dataset comprising experimentally measured sensitivities for 625 unique high‐explosive molecules is augmented with physics‐informed synthetic ...
Grant Hutchings, Jack V. Davis, Virginia W. Manner, Marc J. Cawkwell, Frank W. Marrs   +4 more
wiley   +1 more source

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source

Characterization of Ultrafast Decomposition Dynamics in Nitrate Esters

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT Ignition of energetic materials initiates chemical reactions on atomic length scales within femtoseconds, making these reactions difficult to investigate experimentally. The technique of femtosecond time‐resolved mass spectrometry (FTRMS) can capture molecular rearrangement and bond‐breaking events in isolated molecules with sub‐50 femtosecond
Madison K. Minvielle, Erica Britt, Hugo A. López Peña, Katharine Moore Tibbetts   +3 more
wiley   +1 more source

Toxicity of aqueous extracts of Ilex paraguariensis A.St.‐Hil. about Euphorbia heterophylla L.

Pest Management Science, EarlyView.
Aqueous extracts of Ilex paraguariensis A.St.‐Hil. strongly inhibit Euphorbia heterophylla L. germination and early seedling growth, but show mild phytotoxicity on mature plants, paradoxically promoting biomass via antioxidants. Abstract BACKGROUND The escalating challenge of herbicide‐resistant weeds, exemplified by Euphorbia heterophylla L.
Tamara Alberton da Silva, Ikram Bashir, Ana Caroline Giacomin, Jéssica Adriane Barth, Marina Chiapperin, Fabieli Zanotelli de Oliveira, Camila Thaís Scheibler, Fernanda Bruxel, Elisete Maria de Freitas   +8 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Asiatic Acid Ameliorates MNNG‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis

Phytotherapy Research, EarlyView.
ABSTRACT Chronic atrophic gastritis (CAG), a widespread gastrointestinal condition, is widely acknowledged as a precursor to gastric cancer (GC). The incidence of CAG has been steadily increasing, yet effective pharmacological interventions remain unavailable. Asiatic acid (AA), a bioactive triterpenoid isolated from Centella asiatica, has demonstrated
Feifei Zhou, Cuiyu Zhu, Wanwan Yuan, Wenkun Peng, Qianqian Xu, Hongli Yang, Ruofan Cao, Ben Wang, Meiqian Wang, Hongwei Xu   +9 more
wiley   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Highly electrophilic, <i>gem-</i> and <i>spiro-</i>activated trichloromethylnitrocyclopropanes: synthesis and structure. [PDF]

Beilstein J Org Chem
Pilipenko IA, Grigoriev MV, Ozerova OY, Litvinov IA, Spiridonova DV, Vasilyev AV, Makarenko SV.   +6 more
europepmc   +1 more source

A Chiral 2D Sheet for Enhancing GLUT1 Function Through the Interplay of Architecture and Recognition

Small, EarlyView.
We show that both supramolecular architecture and glucose chirality determine biological function. Unlike self‐assembled 0D particles, we assembled with OFN to form 2D sheets. Only the (d)‐sheets with exposed d‐glucose interacted with GLUT1, increasing its expression, promoting glucose uptake, and reducing ROS.
Yerim Kim, Dawoon Lee, Kyuri Kim, Young Yong Kim, Bongjun Yeom, Sunihl Ma, Young‐Hoon Kim, Yongju Kim   +7 more
wiley   +1 more source