Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania. [PDF]
PLoS Pathogens, 2016 Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment
Susan Wyllie +7 more
doaj +6 more sources
Interrupted Nef and Meyer Reactions: A Growing Point for Diversity-Oriented Synthesis Based on Nitro Compounds [PDF]
Molecules, 2023 The Nef reaction (nitro to carbonyl group conversion) and related Meyer reaction are among the key transformations of aliphatic nitro compounds. The interrupted versions of these reactions in which the normal pathway is redirected to a different end ...
Alexey Yu. Sukhorukov
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The Diverse Biological Activity of Recently Synthesized Nitro Compounds [PDF]
Pharmaceuticals, 2022 The search for new and efficient pharmaceuticals is a constant struggle for medicinal chemists. New substances are needed in order to treat different pathologies affecting the health of humans and animals, and these new compounds should be safe ...
Saúl Noriega +4 more
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A Comprehensive Review on Adsorption, Photocatalytic and Chemical Degradation of Dyes and Nitro-Compounds over Different Kinds of Porous and Composite Materials [PDF]
Molecules, 2023 Dye and nitro-compound pollution has become a significant issue worldwide. The adsorption and degradation of dyes and nitro-compounds have recently become important areas of study. Different methods, such as precipitation, flocculation, ultra-filtration,
Abdul Haleem +3 more
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Catalytic Reduction of Aromatic Nitro Compounds to Phenylhydroxylamine and Its Derivatives [PDF]
MoleculesPhenylhydroxylamine and its derivates (PHAs) are important chemical intermediates. Phenylhydroxylamines are mainly produced via the catalytic reduction of aromatic nitro compounds.
Min Yu +3 more
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Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2017 The title nitropyrrole-based compounds, C7H8N2O4, (I) (ethyl 4-nitro-1H-pyrrole-2-carboxylate), its derivative C12H14N2O4, (II) [ethyl 4-nitro-1-(4-pentynyl)-1H-pyrrole-2-carboxylate], C15H26N4O3, (III) {N-[3-(dimethyamino)propyl]-1-isopentyl-4-nitro-1H ...
Alan R. Kennedy +3 more
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Green Chemical Engineering, 2022 Development of the economic, environmentally friendly synthesis of amines from nitro compounds remains important and challenging. In this work, the graphene shell encapsulated none noble Ni-based catalysts were successfully designed and synthesized via ...
Jianguo Liu +3 more
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Catalytic Reductive Amination of Aldehydes and Ketones With Nitro Compounds: New Light on an Old Reaction [PDF]
Frontiers in Chemistry, 2020 Reductive amination of carbonyl compounds with primary amines is a well-established synthetic methodology for the selective production of unsymmetrically substituted secondary and tertiary amines.
Alexey Yu. Sukhorukov +1 more
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Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines [PDF]
Pharmaceuticals, 2018 The current concept in searching for new bioactive products, including mainly original active substances with potential application in pharmacy and medicine, is based on compounds with a previously determined structure, well-known properties, and ...
Dorota Olender +2 more
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Radiosensitization by non-nitro compounds
International Journal of Radiation Oncology*Biology*Physics, 1982 The effects of 23 non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or E. coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative electron-withdrawing groups are described; the dicyanovinyl function conferred considerable radiosensitizing activity.
P, Wardman +6 more
openaire +3 more sources