New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio +20 more
core +3 more sources
Evaluation of a TiO2 photocatalysis treatment on nitrophenols and nitramines contaminated plant wastewaters by solid-phase extraction coupled with ESI HPLC–MS [PDF]
, 2009 Nitration reactions of aromatic compounds are commonly involved in different industrial processes for pharmaceutical, pesticide or military uses. For many years, most of the manufacturing sites used lagooning systems to treat their process effluents.
Hafidi, Mohamed +5 more
core +3 more sources
ANALYSIS OF SOME FACTORS WHICH CONTRIBUTE TO NITRO INTOXICATION OF ANIMALS [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2019 The accumulation of nitro compounds in plants depends on several factors, in particular: the doses and frequency of incorporation of organic and mineral fertilizers in the soil, the amount of nitro compounds accumulated in soil and plants, climatic ...
Larisa CREMENEAC, Valentina ABRAMOVA
doaj
E-Journal of Chemistry, 2011 Six novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8 ...
Abbas Ahmadi, Babak Nahri-Niknafs
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Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]
, 2015 OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew +5 more
core +3 more sources
Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists [PDF]
, 2015 Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the data collections and the EPSRC National Mass Spectrometry Service (University of Swansea) for the HRMS data.
Harrison, William T. A. +4 more
core +2 more sources
Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules [PDF]
, 2012 Acknowledgements We thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A.
Altomonte, Stefano, Zanda, Matteo
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Scientia PharmaceuticaA series of nine nitro group-containing chalcones were synthesized to investigate their anti-inflammatory and vasorelaxant activities via in vivo, ex vivo, and in silico studies.
Alam Yair Hidalgo +10 more
doaj +1 more source
Performance of the ALOGPS 2.1 program for octanol-water partition coefficient prediction with organic chemicals on the Canadian Domestic Substances List [PDF]
, 2010 The KOWWIN and ALOGPS octanol-water partition coefficient (K~ow~) estimation software programs were compared for their capacity to accurately predict log K~ow~ values of 1545 organic compounds on the publicly available Domestic Substances List (DSL) from
Kaya Forest, Sierra Rayne
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source