Results 61 to 70 of about 3,419,892 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Nitrogen retention in the riparian zone of watersheds underlain by discontinuous permafrost [PDF]

open access: yes, 2005
Thesis (M.S.) University of Alaska Fairbanks, 2005Riparian zones function as important ecotones for reducing nitrate concentration in groundwater and inputs into streams.
O'Donnell, Jonathan A.
core  

Novel Rubidium Poly-Nitrogen Materials at High Pressure

open access: yes, 2017
First-principles crystal structure search is performed to predict novel rubidium poly-nitrogen materials at high pressure by varying the stoichiometry, i. e. relative quantities of the constituent rubidium and nitrogen atoms.
Oleynik, van I.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Anthropogenic nitrogen autotrophy and heterotrophy of the world's watersheds: Past, present, and future trends [PDF]

open access: yes, 2010
Anthropogenic nitrogen autotrophy of a territory is defined as the nitrogen flux associated with local production of harvested crops and grass consumed by livestock grazing (in kg N/km(2)/yr).
Beusen, A.   +3 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Total Nitrogen Concentrations in Wastewater Treatment Plant Effluent in the Great Bay Estuary Watershed in 2008 [PDF]

open access: yes, 2008
Nitrogen enrichment is a growing concern for the Great Bay Estuary. For the 2006 State of the Estuaries report (NHEP, 2006), the NHEP calculated the nitrogen load from wastewater treatment facilities (WWTF) using data on total dissolved nitrogen in WWTF ...
Trowbridge, Philip
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

RNA-Seq study reveals genetic responses of diverse wild soybean accessions to increased ozone levels

open access: yesBMC Genomics, 2017
Background Ozone is an air pollutant widely known to cause a decrease in productivity in many plant species, including soybean (Glycine max (L.) Merr).
Nathan Waldeck   +5 more
doaj   +1 more source

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