Results 81 to 90 of about 3,419,892 (288)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Influence of Nitrogen in Ar+N2 Mixture on Parameters of High-Temperature Device with Electric Arc

Acta Polytechnica, 2013
The paper presents the results of numerous experiments carried out on a high temperature device consisting of an arc heater with intensively blasted electric arc and reaction chambers connected to its output. The influence of nitrogen mass concentration (
Ivana Jakubova, Josef Senk, Ilona Laznickova   +2 more
doaj  

Biomimetic synthesis of vesicular covalent organic frameworks by gemini surfactants for in-situ enzyme cascade immobilization

Nature Communications
In nature, enzymes in biofilms often lack robustness and chemical functionality. Covalent organic frameworks (COFs) have emerged as a robust platform for enzyme immobilization, but mimicking biofilm structures for in-situ enzyme immobilization remains ...
Jin Zhang, You Li, Jiaxuan Li, Lin Zhu, Shangbin Jin   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A data-driven reduced-order model for fast prediction of resonant acoustic flow under vertical vibration based on secondary decomposition

AIP Advances
Accurate dimensionality reduction models are crucial for constructing real-time computational digital twin systems for process equipment. To deepen the understanding of acoustic resonance flow mechanisms and optimize equipment design, a high-precision ...
Yuqi Gao, Ning Ma, Shifu Zhu, Pengchao Zhang, Hongxing Liu, Zhongyuan Xie   +5 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Nitrogen retention/enrichment of 316LN austenitic stainless steel welds [PDF]

, 2006
The development of nitrogen enriched austenitic stainless steels has been a source of recent interest due to the abundant availability of nitrogen and by the manner in which nitrogen contributes several beneficial material property effects over a wide ...
Galloway, Alexander, McPherson, Norman
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Nitrogen fixing shade trees in coffee agroforestry: Quantification of nitrogen transfer to the coffee plant [PDF]

, 2019
Nitrogen-fixing shade trees in coffee agroforestry systems are assumed to provide an alternative nitrogen source for the coffee crop when fertilizer applications are low, but the transfer of nitrogen from shade trees to the coffee crop has not yet been ...
Blanchart, Eric, Harmand, Jean-Michel, Van Den Meersche, Karel, Zeller, Bernd   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source