Results 81 to 90 of about 1,110,939 (298)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Metabolic Network Analysis Reveals Human Impact on Urban Nitrogen Cycles

open access: yesLand
Human interactions have led to the emergence of a higher complexity of urban metabolic networks; hence, traditional natural- or agriculture-oriented biogeochemical models might not be transferred well to urban environments.
Yong Min, Hong Li, Ying Ge, Jie Chang
doaj   +1 more source

Parallel functional and stoichiometric trait shifts in South American and African forest communities with elevation [PDF]

open access: yes, 2017
The Amazon and Congo basins are the two largest continuous blocks of tropical forest with a central role for global biogeochemical cycles and ecology. However, both biomes differ in structure and species richness and composition.
C. Taveirne   +8 more
core   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Hydrology and oxygen addition drive nutrients, metals, and methylmercury cycling in a hypereutrophic water supply reservoir

open access: yesFrontiers in Water
Impaired water quality in Mediterranean climate reservoirs is mainly associated with eutrophication and internal nutrient loading. To improve water quality in hypereutrophic Hodges Reservoir, California, United States, a hypolimnetic oxygenation system ...
Naivy Dennise Rodal-Morales   +8 more
doaj   +1 more source

Responses of an Agricultural Soil Microbiome to Flooding with Seawater after Managed Coastal Realignment

open access: yesMicroorganisms, 2018
Coastal areas have become more prone to flooding with seawater due to climate-change-induced sea-level rise and intensified storm surges. One way to cope with this issue is by “managed coastal realignment”, where low-lying coastal areas are no longer ...
Kamilla S. Sjøgaard   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Long term nitrogen budget modelling in a small agricultural watershed: hydrological control assessment of nitrogen losses with semi-distributed (SWAT) and distributed (TNT2) models [PDF]

open access: yes, 2009
Nitrogen exports in catchments are known to be greatly variable because nitrogen cycle in watershed is controlled by different factors such as landuse, farm management practices, climate, soil type and hydrological setting.
Durand, Patrick   +5 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Inventories and scenarios of nitrous oxide emissions

open access: yesEnvironmental Research Letters, 2014
Effective mitigation for N _2 O emissions, now the third most important anthropogenic greenhouse gas and the largest remaining anthropogenic source of stratospheric ozone depleting substances, requires understanding of the sources and how they may ...
Eric A Davidson, David Kanter
doaj   +1 more source

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