Results 171 to 180 of about 170,686 (314)

The importance of dissolved organic nutrients in the biogeochemistry of oligotrophic gyres

open access: yes, 2005
The aim of this thesis is to contribute to the observational database in order to address fundamental questions as to how dissolved organic nutrients influence N and P budgets, how they affect nutrient cycling and the sustainment of biological production
Landolfi, Angela
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao   +7 more
wiley   +1 more source

Analysis of the carbon and nitrogen limitations to soybean yield

open access: yes, 1976
Soybeans are hypothesized to be “self-destructive” since they apparently need to translocate large amounts of nitrogen from vegetative tissues during seed-fill to sustain seed growth.
Wit, C.T., de   +2 more
core  

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

open access: yesAdvanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang   +11 more
wiley   +1 more source

Interaction of Azospirillum lipoferum with wheat germ agglutinin stimulates nitrogen fixation

open access: yes, 1999
In vitro, the nitrogen fixation capability of A. lipoferum is efficiently increased in the presence of wheat germ agglutinin (WGA). A putative WGA-binding receptor, a 32-kDa protein, was detected in the cell capsule.
Kiss, Péter   +5 more
core  

Lowering the Mo limit for nitrogen fixation by Mo-nitrogenase. [PDF]

open access: yesCommun Earth Environ
Stevenson Z   +6 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

open access: yesAdvanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang   +16 more
wiley   +1 more source

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