Results 211 to 220 of about 35,458 (292)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Sulfur Isotopes Reveal Spatial Variation in Waterbird Trace Element Contamination from Tropical Estuaries to the Open Ocean. [PDF]

Environ Sci Technol
Linhares BA, Bustamante P, Nunes GT, Costa PG, Bugoni L, Zebral YD, Orselli IBM, Martins CMG, Bianchini A.   +8 more
europepmc   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

C, H, O, N Stable Isotope Analysis Coupled with Chemometrics for Geographic Origin Authentication of Pacific White Shrimp (<i>Litopenaeus vannamei</i>) in China. [PDF]

Foods
Wang N, Wang C, Wang H, Zhang L, Zhang M, Jing H, Mei L, Qiu S, Liu X, Lv J, Wu S.   +10 more
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Multi-isotope analysis reconstructs termite feeding in chimpanzees. [PDF]

Sci Rep
Brömme S, Oelze VM, Martínez-García A, Leichliter JN, Haug GH, Vonhof HB, Stewart FA, Piel AK, Lüdecke T.   +8 more
europepmc   +1 more source

Steric modulation of nitric oxide photodissociation kinetics in iron–nitrosyl complexes

Bulletin of the Korean Chemical Society, EarlyView.
Subtle steric modification within a pyridinophane ligand framework modulates nitric oxide photodissociation kinetics in iron–nitrosyl complexes. Structural and electrochemical analyses reveal that modest ligand‐environment variations are reflected in differences in NO photoreactivity.
Jisu Choe, Jaeheung Cho
wiley   +1 more source

Classifying avian drinking behaviour: ecological insights and implications in a changing world

Biological Reviews, EarlyView.
ABSTRACT Water is a fundamental currency of life, and its availability significantly influences animal behaviour, physiology and distributions. However, our knowledge around the dependence on water for drinking and the direct and indirect mechanisms driving related behaviours remains partial in the context of changing climates. Here, we review patterns
Shannon R. Conradie, Marc T. Freeman
wiley   +1 more source

Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry to ¹⁵N Natural Abundance in Cancer. [PDF]

Int J Mol Sci
Tea I, Tcherkez G.
europepmc   +1 more source

Effects of Wheat Bran‐Derived Arabinoxylan Oligosaccharides on Dough and Noodle‐Making Properties

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study investigates the structural modifications of arabinoxylan (AX) through enzymatic hydrolysis and evaluates the potential application of arabinoxylan oligosaccharides (AXOS) as functional ingredients in wheat noodles, contrasting their effects with those of native AX.
Yunseo Kim, Meera Kweon
wiley   +1 more source