Results 111 to 120 of about 3,692,508 (293)

Acute effect of nitroglycerin on cyclosporine-induced hypertension after cardiac transplantation [PDF]

, 2010
BACKGROUND: Cyclosporine represents a milestone in immunosuppression following organ transplantation. Its use, however, comes at the cost of significant side effects, such as arterial hypertension which is rarely controllable by currently available anti ...
Enseleit, F, Farshad, M, Flammer, A J, Periat, D, Spieker, L, Sudano, I   +5 more
core   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Clinical connectivity map for drug repurposing: using laboratory tests to bridge drugs and diseases [PDF]

arXiv, 2020
Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets), resulting in translational problems for clinical trials.
arxiv  

Endothelin receptor antagonists in a beagle model of pulmonary hypertension: Contribution to possible potential therapy? [PDF]

, 1995
Objectives.This study investigated the pharmacologic effect of endothelin receptor antagonists on cardiopulmonary hemodynamic variables in a beagle model of pulmonary hypertension.Background.We recently developed a beagle model of pulmonary hypertension ...
Okada, Kenji, Okada, Masayoshi, Okada, Morihito, Yamashita, Chojiro   +3 more
core   +1 more source

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +1 more source

Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Scientific Reports, 2023
Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model occupies a prominent place, but there is relatively insufficient information about how NTG affects intracranial vessels.
Alexey Y. Sokolov, Maxim A. Volynsky, Anastasiia V. Potapenko, Polina M. Iurkova, Valeriy V. Zaytsev, Ervin Nippolainen, Alexei A. Kamshilin   +6 more
doaj   +1 more source

The effect of listening to the voice recording of relatives on chest pain, anxiety and depression in patients hospitalized in the coronary intensive care unit: A randomized controlled trial

Nursing in Critical Care, EarlyView.
Abstract Background After acute myocardial infarction, the prevalence of anxiety and depression is quite high in patients because of severe chest pain, distance from relatives, unfamiliar environment and orientation problems. Aim To assess the effect of listening to the voice recordings of relatives of patients with acute myocardial infarction who were
Yasemin Kalkan Uğurlu, Dilek Küçük Alemdar   +1 more
wiley   +1 more source

Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug [PDF]

Cardiovascular Research, 2018
Abstract Aims Nitroglycerine (NTG) given prior to an ischaemic insult exerts cardioprotective effects. However, whether administration of an acute low dose of NTG in a clinically relevant manner following an ischaemic episode limits infarct size, has not yet been explored.
Peter Brouckaert, Voahanginirina Randriamboavonjy, Efstathios K. Iliodromitis, Sofia-Iris Bibli, Sofia-Iris Bibli, Ingrid Fleming, Kyriakos E. Kypreos, Athanasia Chatzianastasiou, Andreas Daiber, Andreas Papapetropoulos, Ioanna Andreadou, Derek J. Hausenloy, Sebastian Steven   +12 more
openaire   +4 more sources

Coronary Spasm Due to Pulsed Field Ablation: A State‐of‐the‐Art Review

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT With the ever‐growing population of patients undergoing cardiac ablation with pulsed electric fields, there is a need to understand secondary effects from the therapy. Coronary artery spasm is one such effect that has recently emerged as the subject of further investigation in electrophysiology literature.
David A. Ramirez, Kara Garrott, Ann Garlitski, Brendan Koop   +3 more
wiley   +1 more source

Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Neurobiology of Pain, 2022
Migraine is one of the most common pain disorders and causes disability in millions of people every year. Delta opioid receptors (DOR) have been identified as a novel therapeutic target for migraine and other headache disorders.
Zachariah Bertels, Isaac J. Dripps, Pal Shah, Laura S. Moye, Alycia F. Tipton, Kendra Siegersma, Amynah A. Pradhan   +6 more
doaj