Nitroglycerin as a Hypotensive Drug during General Anesthesia [PDF]
Survey of Anesthesiology, 1978 Circulatory variables and arterial partial pressure for oxygen (PaO2) were compared in 91 anesthetized patients who received infusions of either nitroglycerin (TNG) or nitroprusside (SNP) to induce hypotension for the purpose of decreasing intraoperative blood loss.
N. R. Fahmy
semanticscholar +6 more sources
Head-up tilt testing potentiated with oral nitroglycerin; a randomized trial of the contribution of a drug-free phase and a nitroglycerin phase in the diagnosis of neurally mediated syncope [PDF]
Europace, 1999 Since the pharmacological challenge with nitroglycerin (NTG) follows the initial drug-free phase in current tilt testing protocols, the effects of nitroglycerin alone and the appropriate duration of the basal phase are unknown.To optimize the test, a randomized intra-patient comparison of two protocols was undertaken: a conventional nitroglycerin test (
Angelo Bartoletti +9 more
semanticscholar +5 more sources
The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. [PDF]
Circulation, 1981 The effect of sublingual or intracoronary nitroglycerin (NTG) on luminal caliber in normal and diseased portions of epicardial coronary arteries was determined in 85 lesions from 57 typical patients with ischemic heart disease. Measurements were made from coronary angiograms, using a computer-assisted method and a carefully blinded protocol for ...
B GBrown +4 more
semanticscholar +5 more sources
The auditory function in migraine model rats induced by postauricular nitroglycerin injection
Frontiers in Neurology, 2023 ObjectiveThe mechanism by which migraines produce inner ear-related symptoms is not well understood. Previous studies have found that the latency of auditory brainstem response (ABR) in animal models of migraine has changed, but the threshold has not ...
Rongxiang Qi +3 more
doaj +2 more sources
Nitroglycerin—the first one hundred years: new facts about an old drug [PDF]
Journal of Pharmacy and Pharmacology, 1979 James R Parr Att
semanticscholar +5 more sources
Recent Advancement of Medical Patch for Transdermal Drug Delivery
Medicina, 2023 Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body.
Won Fen Wong +3 more
doaj +2 more sources
Circulation, 2003 Newer drugs quickly replace older remedies. This has not been the case with nitroglycerin, now in continuous medical use for more than a century. Although other applications for it have been found in cardiology, nitroglycerin is the mainstay for affording rapid, indeed almost immediate, relief for angina pectoris.
Thomas B. Graboys, Bernard Lown
openaire +3 more sources
BMC Anesthesiology, 2020 Background Deliberate hypotension is used to provide a bloodless field during functional endoscopic sinus surgery; however, the impact of controlled hypotension during anesthesia on peripheral tissue perfusion has not been extensively evaluated.
Marwa Zayed +11 more
doaj +2 more sources
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application [PDF]
Cancer Science, 2009 Dose regimens of anticancer agents are usually designed on the basis of the maximum tolerable drug doses, and toxicity prevents drug usage at higher doses, even though the drugs may be more effective at the higher doses. We previously studied macromolecular anticancer drugs, i.e.
Takahiro Seki, Jun Fang, Hiroshi Maeda
openalex +5 more sources
Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. [PDF]
Journal of Clinical Investigation, 1996 Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide dinitrate. Recently, we demonstrated that nitrate tolerance is in part due to enhanced vascular superoxide .O2- production ...
Thomas Münzel +7 more
openalex +2 more sources