Results 201 to 210 of about 3,766,051 (278)
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Transdermal nitroglycerin as a step 3 antihypertensive drug
Clinical Pharmacology and Therapeutics, 1986The antihypertensive effect of transdermal nitroglycerin was tested in 11 men with hypertension (mean age 60 years) whose diastolic blood pressure exceeded 90 mm Hg while receiving a diuretic and a beta-adrenergic blocker. In a double-blind, randomized crossover trial the subjects received weekly increments of placebo or nitroglycerin (5, 10, 20, and ...
Jay N. Cohn +2 more
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Assessment of the Drug Interaction Between Alteplase and Nitroglycerin: An In Vitro Study
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2000 Alteplase is the most commonly administered thrombolytic agent in the United States. However, concurrent therapy with nitroglycerin reduces plasma alteplase concentrations and its clinical efficacy. We sought to determine if this interaction is concentration and pH dependent. Seventy plasma samples were prepared and divided into three groups: alteplase
C Michael White +4 more
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The medical treatment of angina pectoris IV. Nitroglycerin as an antianginal drug
American Heart Journal, 1972 Wilbert S. Aronow
semanticscholar +5 more sources
BIOEQUIVALENCE COMPARISON OF TWO DRUG-IN-ADHESIVE TRANSDERMAL NITROGLYCERIN PATCHES
American Journal of Therapeutics, 1996Plasma concentrations of nitroglycerin, 1,2-dinitroglycerin and 1,3-dinitroglycerin in 50 healthy male subjects who received single 24-h applications of two 0.6 mg/h drug-in-adhesive transdermal nitroglycerin patch formulations were compared for the purpose of establishing bioequivalence.
Jeff M. Zumhofe +7 more
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Absence of Drug Interaction Between Heparin and Nitroglycerin
Archives of Internal Medicine, 1990The purpose of this randomized crossover study was to determine whether nitroglycerin interacts with heparin in terms of its anticoagulative properties as determined by activated partial thromboplastin time and thrombin time. Eight healthy adults were given either a 60-minute intravenous infusion of 5 mg of nitroglycerin or a 0.9% sodium chloride ...
U. Polensky +3 more
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Transdermal nitroglycerin prevents nonsteroidal anti-inflammatory drug gastropathy
European Journal of Pharmacology, 1995Abstract The application of a transdermal nitroglycerin patch (2–30 μg/3 h/rat) protected, in a dose-dependent manner, the rat gastric mucosa against damage induced by the nonsteroidal anti-inflammatory agent indomethacin (20 mg/kg s.c.).
M D Barrachina +6 more
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Adhesive Matrix Type Transdermal Drug Delivery System for Nitroglycerin
Drug Development and Industrial Pharmacy, 1994AbstractThe kinetics of release of nitroglycerin from adhesive matrix type patches was studied. At a high drug to adhesive ratio the patch consisted of nitroglycerin in part dispersed as droplets in the adhesive and in part dissolved in the adhesive.
Meenal S. Desai +3 more
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Transdermal Absorption of Nitroglycerin from Microseal Drug Delivery (MDD) System
Angiology, 1983A recent important advance in biopharmaceutics has been the utilization of controlled delivery of drugs to the systemic circulation through the intact skin. With the conventional tablet and capsule dosage forms, the amount of drug absorbed through the gastrointestinal (GI) tract varies depending on the quan tity and types of food in the stomach, on ...
A. Karim
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Relief of coronary artery spasm by nitroglycerin: Time‐dependent variability in drug action
Catheterization and Cardiovascular Diagnosis, 1978AbstractThe arteriographic distinction between a fixed atheromatous obstruction and localized vasospasm in the coronary artery is often decided by the response of the lesion to nitroglycerin. We studied the time course of nitroglycerin in four patients with coronary artery spasm as revealed by selective angiography.
Harold O. Stolberg +4 more
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The human NTG model of migraine in drug discovery and development
Expert Opinion on Drug Discovery, 2023Introduction Various triggers can originate a migraine attack. In healthy volunteers and patients with migraine, the nitroglycerin (NTG) provocation model induces a headache that resembles migraine in pain characteristics and vascular manifestations ...
Lanfranco Pellesi
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