Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition. [PDF]
Jiang S, Ding Y, Wang H, Kim E, Geng X.
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[Nitroglycerin: secular drug always current].
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Nitroglycerin: New concepts about an old drug [PDF]
Abstract Increasing evidence has profoundly challenged previously accepted concepts about the actions and clinical uses of nitroglycerin. Traditionally, use of this agent has been contraindicated in patients with acute myocardial infarction because of its hypotensive effects, and it has had no place in the therapeutic armamentarium of heart failure or
Richard H. Helfant
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Homicide and nitroglycerin. A case of drug interaction
Examines the mysterious circumstances surrounding the death of a young woman in 1901 and the possibility that it was due to drinking nitroglycerin.
Frederick J. Di Carlo, Linda Culp Holmes
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Influence of Formulating Factors on Drug Safety of Timed-Release Nitroglycerin Tablets
A peroral sandwich model tablet with timed release, containing proxyphylline and nitroglycerin, was developed. One layer of the tablet constituted the rapidly disintegrating and dissolving initial phase; the other, the depot phase, was in the form of an insoluble, indigestible skeleton.
W. A. Ritschel
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Effect of intermittent exposure and drug-free intervals on the vascular tolerance to nitroglycerin
Recent reports suggest that intermittent nitroglycerin (NTG) treatment, incorporating a daily nitrate-free interval, can avoid the tolerance associated with continuous NTG therapy. This study has investigated whether an in vitro model of NTG tolerance could be used to examine the mechanisms of tolerance avoidance (by intermittent NTG exposure) and ...
Elizabeth A. Kowaluk+2 more
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Assessment of the Drug Interaction between Intravenous Nitroglycerin and Heparin
Annals of Pharmacotherapy, 1992OBJECTIVE: To assess whether a clinically significant interaction occurs between heparin and nitroglycerin (NTG). METHODOLOGY: Activated partial thromboplastin time (APTT) was measured in patients with unstable angina who were stabilized on intravenous NTG and heparin just prior to weaning the NTG infusion, and one and four hours after stopping the NTG.
Susan Graham+3 more
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Transdermal nitroglycerin as a step 3 antihypertensive drug
Clinical Pharmacology and Therapeutics, 1986The antihypertensive effect of transdermal nitroglycerin was tested in 11 men with hypertension (mean age 60 years) whose diastolic blood pressure exceeded 90 mm Hg while receiving a diuretic and a beta-adrenergic blocker. In a double-blind, randomized crossover trial the subjects received weekly increments of placebo or nitroglycerin (5, 10, 20, and ...
Jay N. Cohn+2 more
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Transdermal Absorption of Nitroglycerin from Microseal Drug Delivery (MDD) System
Angiology, 1983A recent important advance in biopharmaceutics has been the utilization of controlled delivery of drugs to the systemic circulation through the intact skin. With the conventional tablet and capsule dosage forms, the amount of drug absorbed through the gastrointestinal (GI) tract varies depending on the quan tity and types of food in the stomach, on ...
A. Karim
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BIOEQUIVALENCE COMPARISON OF TWO DRUG-IN-ADHESIVE TRANSDERMAL NITROGLYCERIN PATCHES
American Journal of Therapeutics, 1996Plasma concentrations of nitroglycerin, 1,2-dinitroglycerin and 1,3-dinitroglycerin in 50 healthy male subjects who received single 24-h applications of two 0.6 mg/h drug-in-adhesive transdermal nitroglycerin patch formulations were compared for the purpose of establishing bioequivalence.
Jeff M. Zumhofe+7 more
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