Results 221 to 230 of about 3,692,508 (293)
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Transdermal nitroglycerin prevents nonsteroidal anti-inflammatory drug gastropathy
European Journal of Pharmacology, 1995Abstract The application of a transdermal nitroglycerin patch (2–30 μg/3 h/rat) protected, in a dose-dependent manner, the rat gastric mucosa against damage induced by the nonsteroidal anti-inflammatory agent indomethacin (20 mg/kg s.c.).
M D Barrachina +6 more
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Absence of Drug Interaction Between Heparin and Nitroglycerin
Archives of Internal Medicine, 1990The purpose of this randomized crossover study was to determine whether nitroglycerin interacts with heparin in terms of its anticoagulative properties as determined by activated partial thromboplastin time and thrombin time. Eight healthy adults were given either a 60-minute intravenous infusion of 5 mg of nitroglycerin or a 0.9% sodium chloride ...
U. Polensky +3 more
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Assessment of the Drug Interaction Between Alteplase and Nitroglycerin: An In Vitro Study
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2000 Alteplase is the most commonly administered thrombolytic agent in the United States. However, concurrent therapy with nitroglycerin reduces plasma alteplase concentrations and its clinical efficacy. We sought to determine if this interaction is concentration and pH dependent. Seventy plasma samples were prepared and divided into three groups: alteplase
C Michael White +4 more
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The medical treatment of angina pectoris IV. Nitroglycerin as an antianginal drug
American Heart Journal, 1972 Wilbert S. Aronow
semanticscholar +5 more sources
Pulsed release of nitroglycerin from transdermal drug delivery systems
International Journal of Pharmaceutics, 1999To achieve a discontinuous drug delivery to the skin a new actively controlled transdermal system has been developed. The system consists of a tube shaped drug reservoir in combination with an electronic circuit and a gas producing cell. A magnetic switch was used to control the onset of the production of hydrogen gas.
R. Gröning, U Kuhland
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Adhesive Matrix Type Transdermal Drug Delivery System for Nitroglycerin
Drug Development and Industrial Pharmacy, 1994AbstractThe kinetics of release of nitroglycerin from adhesive matrix type patches was studied. At a high drug to adhesive ratio the patch consisted of nitroglycerin in part dispersed as droplets in the adhesive and in part dissolved in the adhesive.
Meenal S. Desai +3 more
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Relief of coronary artery spasm by nitroglycerin: Time‐dependent variability in drug action
Catheterization and Cardiovascular Diagnosis, 1978AbstractThe arteriographic distinction between a fixed atheromatous obstruction and localized vasospasm in the coronary artery is often decided by the response of the lesion to nitroglycerin. We studied the time course of nitroglycerin in four patients with coronary artery spasm as revealed by selective angiography.
Harold O. Stolberg +4 more
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Survey of Anesthesiology, 1988 Intravenous (IV) nitroglycerin was found to interfere with the anticoagulant effect of heparin during eight infusions of both drugs in seven patients who were closely monitored with frequent activated partial thromboplastin time determinations.
Moh’d A. Habbab, Jacob I. Haft
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The human NTG model of migraine in drug discovery and development
Expert Opinion on Drug Discovery, 2023Introduction Various triggers can originate a migraine attack. In healthy volunteers and patients with migraine, the nitroglycerin (NTG) provocation model induces a headache that resembles migraine in pain characteristics and vascular manifestations ...
Lanfranco Pellesi
semanticscholar +1 more source
Antianginal drugs. Part II. Human pharmacology of nitroglycerin
American Heart Journal, 1966 Solomon Fisch
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