Results 31 to 40 of about 21,843 (261)

Triptans and CGRP blockade - impact on the cranial vasculature [PDF]

, 2017
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez, Anne Luise Vollesen, Christian Lampl, Francesca Cortese, Francesca Marchese, Lanfranco Pellesi, Messoud Ashina, Michele Romoli, On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Silvia Benemei   +9 more
core   +3 more sources

Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Neurobiology of Pain, 2022
Migraine is one of the most common pain disorders and causes disability in millions of people every year. Delta opioid receptors (DOR) have been identified as a novel therapeutic target for migraine and other headache disorders.
Zachariah Bertels, Isaac J. Dripps, Pal Shah, Laura S. Moye, Alycia F. Tipton, Kendra Siegersma, Amynah A. Pradhan   +6 more
doaj   +1 more source

Isosorbide dinitrate, with or without hydralazine, does not reduce wave reflections, left ventricular hypertrophy, or myocardial fibrosis in patients with heart failure with preserved ejection fraction [PDF]

, 2017
Background-Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling.
Akers, Scott, Beraun, Melissa, Chirinos, Julio A., Chittams, Jesse, Haines, Philip G., Koppula, Maheswara R., Rawat, Deepa, Segers, Patrick, Shiva-Kumar, Prithvi, Soto-Calderon, Haideliza, Townsend, Raymond R., Varakantam, Swapna, Witschey, Walter R., Zamani, Payman   +13 more
core   +1 more source

Nesiritide: Harmful or Harmless? [PDF]

, 2006
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90328/1/phco.26.10.1465 ...
Fett DL, Francis GS, Heywood JT, Heywood JT, Ikram H, Jensen KT, Jo Ellen Rodgers, Lainchbury JG, Marcus LS, Michael P Dorsch, Peacock WF, Van der Zander K, Yoshirmura M   +12 more
core   +1 more source

Immunohistochemical evidences of anticancer actions of metformin with other repurposed drug combinations and correlation with hamster fibrosarcoma tumor size [PDF]

Journal of the Serbian Chemical Society
The aim was to detect and correlate anticancer effects of metformin in combinations with other repurposed drugs, already registered for other indications, which may be immediately applied and clinically investigated in oncology, reducing the time and ...
Popović Jovan K., Popović Dušica J., Popović Kosta J., Miljković Dejan, Lalošević Dušan, Dolićanin Zana, Čapo Ivan   +6 more
doaj   +1 more source

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans [PDF]

, 2015
Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined.
Alexander, Alexander, Angelo, Badejo, Bailey, Baliga, Basu, Chen, Cosby, D'Souza, Dejam, DiFabio, Doyle, Furchgott, Ghosh, Gladwin, Golwala, Greenstein, Huellner, Huffman, Irvine, Johansson, Keith, Kollau, Koppaka, Larsen, Li, Lundberg, Mackenzie, Madhani, Maher, Maher, Marti, Ormerod, Paneni, Pawson, Perlman, Pinder, Tiso, Totzeck   +39 more
core   +2 more sources

Effects of metformin and its combinations with other repurposed drugs on fibrosarcoma in hamsters [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. Many drugs registered for various other indications can act selectively on tumor receptors, signaling pathways, metabolic processes, bioenergetic factors, enzymes, proteins and genes that regulate tumor proliferation, apoptosis ...
Popović Dušica J., Popović Kosta J., Lalošević Dušan, Popović Jovan K.   +3 more
doaj   +1 more source

Pharmacy intervention at an intensive care rehabilitation clinic [PDF]

, 2016
Introduction: During an intensive care stay, patients often have their chronic medications withheld for a variety of reasons and new drugs commenced [1].
Daniel, M., Devine, H., Fenlon, C., Kinsella, J., MacTavish, P., McPeake, J., Quasim, T.   +6 more
core   +1 more source

P153 Radial-finger Pulse Wave Velocity as a Measure of Microvascular Stiffness: Feasibility and Response to Nitroglycerin

Artery Research, 2020
Background/Objectives: We previously demonstrated a different regional stiffness response of elastic and muscular arteries after the administration of nitroglycerin, leading to an alteration of aortic-brachial stiffness gradient.
Catherine Fortier, Mohsen Agharazii, Charles-Antoine Garneau, Karine Marquis   +3 more
doaj   +2 more sources

THE CHOICE OF NITRATE THERAPY IN PATIENTS WITH STABLE ANGINA: COMPARATIVE STUDY OF ISOSORBIDE DINITRATE (IN USUAL TABLETS) WITH ISOSORBIDE-5-MONONITRATE (IN VARIOUS PRESENTATIONS)

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study efficacy and tolerability of isosorbide-5-mononitrate (IMN) in various presentations in comparison with isosorbide dinitrate (IDN) in usual tablets in patients with stable angina.Material and Methods.
V. A. Egoro, E. V. Shilova, S. Y. Martsevich   +2 more
doaj   +1 more source