Results 61 to 70 of about 3,692,508 (293)

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]

, 2017
Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts, Johnson, Philip Lee, Kunkler, Phillip Edward, Oxford, Gerry Stephen, Zhang, LuJuan   +4 more
core   +1 more source

Isosorbide dinitrate, with or without hydralazine, does not reduce wave reflections, left ventricular hypertrophy, or myocardial fibrosis in patients with heart failure with preserved ejection fraction [PDF]

, 2017
Background-Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling.
Akers, Scott, Beraun, Melissa, Chirinos, Julio A., Chittams, Jesse, Haines, Philip G., Koppula, Maheswara R., Rawat, Deepa, Segers, Patrick, Shiva-Kumar, Prithvi, Soto-Calderon, Haideliza, Townsend, Raymond R., Varakantam, Swapna, Witschey, Walter R., Zamani, Payman   +13 more
core   +1 more source

Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation

Biomolecules, 2022
Glutathione-S-transferases (GSTs) are highly promiscuous in terms of their interactions with multiple proteins, leading to various functions. In addition to their classical detoxification roles with multi-drug resistance-related protein-1 (MRP1), more ...
Tiffany M. Russell, Des R. Richardson
doaj   +1 more source

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve. [PDF]

, 2015
AimsThe mechanistic basis of the symptoms and signs of myocardial ischaemia in patients without obstructive coronary artery disease (CAD) and evidence of coronary microvascular dysfunction (CMD) is unclear.
Anderson, R David, Bairey Merz, C Noel, Berman, Daniel S, Brown, Garrett H, Cook-Wiens, Galen, Handberg, Eileen M, Mehta, Puja K, Minissian, Margo B, Pepine, Carl J, Petersen, John W, Rogatko, André, Shaw, Leslee J, Shufelt, Chrisandra L, Shuster, Jonathan J, Thomson, Louise EJ, Wei, Janet   +15 more
core   +1 more source

Effect of N-methyl-d-aspartate (NMDA) receptor antagonist combination as adjuvant to general anesthesia in functional endoscopic sinus surgery

Ain Shams Journal of Anesthesiology, 2019
Background This randomized, placebo-controlled, double-blind study was designed to assess controlled hypotension using N-methyl-d-aspartate (NMDA) receptor antagonists in patients undergoing functional endoscopic sinus surgery under general anesthesia ...
Karim Youssef Kamal Hakim, Wahba Zakaria Wahba   +1 more
doaj   +1 more source

Triptans and CGRP blockade - impact on the cranial vasculature [PDF]

, 2017
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez, Anne Luise Vollesen, Christian Lampl, Francesca Cortese, Francesca Marchese, Lanfranco Pellesi, Messoud Ashina, Michele Romoli, On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Silvia Benemei   +9 more
core   +3 more sources

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database

Frontiers in Pharmacology, 2019
The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve
Yoshito Zamami, Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, Mitsunobu R. Kano, Keisuke Ishizawa, Keisuke Ishizawa   +20 more
doaj   +1 more source

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans [PDF]

, 2015
Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined.
Alexander, Alexander, Angelo, Badejo, Bailey, Baliga, Basu, Chen, Cosby, D'Souza, Dejam, DiFabio, Doyle, Furchgott, Ghosh, Gladwin, Golwala, Greenstein, Huellner, Huffman, Irvine, Johansson, Keith, Kollau, Koppaka, Larsen, Li, Lundberg, Mackenzie, Madhani, Maher, Maher, Marti, Ormerod, Paneni, Pawson, Perlman, Pinder, Tiso, Totzeck   +39 more
core   +2 more sources

Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation.

PLoS ONE, 2019
We examined the effect of liquorice ingestion on haemodynamic responses to exogenous nitric oxide donor (nitroglycerin) and β2-adrenoceptor agonist (salbutamol), and 11β-hydroxysteroid dehydrogenase activity, in 21 volunteers and 21 reference subjects ...
Elina J Hautaniemi, Antti J Tikkakoski, Arttu Eräranta, Mika Kähönen, Esa Hämäläinen, Ursula Turpeinen, Heini Huhtala, Jukka Mustonen, Ilkka H Pörsti   +8 more
doaj   +1 more source

Multi-View Substructure Learning for Drug-Drug Interaction Prediction [PDF]

arXiv, 2022
Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete and noisy information, which limits the accuracy of DDI prediction.
arxiv