Results 81 to 90 of about 3,729,717 (272)

Different Involvement of ASIC and TRPA1 in Facial and Hindpaw Allodynia in Nitroglycerin-Induced Peripheral Hypersensitivities in Mice

Life, 2022
The pathophysiological mechanism underlying migraine-associated peripheral hypersensitivity remains unclear. Acid-sensing ion channels (ASICs) and transient receptor potential ankyrin 1 (TRPA1) are known to be causative pathogenic factors of mechanical ...
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Dae-Hyun Roh   +3 more
doaj   +1 more source

The metal-nonoate Ni(SalPipNONO) inhibits in vitro tumor growth, invasiveness and angiogenesis [PDF]

, 2018
Nitric oxide (NO) exerts conflicting effect on tumor growth and progression, depending on its concentration. We aimed to characterize the anti-cancer activity of a new NO donor, Ni(SalPipNONO) belonging to the class of metal-nonoates, in epithelial ...
Casella, Luigi, Ciccone, Valerio, Monti, Martina, Monzani, Enrico, Morbidelli, Lucia   +4 more
core   +1 more source

Pulsed Field Ablation for Atrial Fibrillation in Fontan Palliation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Pulsed‐field ablation (PFA) is a novel and effective modality for ablation in patients with atrial fibrillation (AF). Available case reports and small series showed promising results in patients with congenital heart disease. However, PFA ablation in Fontan patients has not been reported yet.
Fouad Khalil, Abhishek J. Deshmukh, Shane T. Tsai   +2 more
wiley   +1 more source

Ventricular Tachycardia Induced by Exercise Test as a Predictor of Coronary Artery Disease Development

Рациональная фармакотерапия в кардиологии, 2019
A long-term clinical observation of the patient with ventricular tachycardia induced by exercise test but without myocardial ischemia and coronary artery atherosclerosis based on the results of angiography in the debut of the disease is described ...
A. A. Tatarinova, E. A. Ryngach, T. V. Treshkur, D. V. Ryzhkova, O. N. Zhdanova, D. V. Svalov   +5 more
doaj   +1 more source

WISE 2005: responses of women to sublingual nitroglycerin before and after 56 days of 6 degrees head-down bed rest [PDF]

, 2012
This study tested the hypothesis that cardiovascular effects of sublingual nitroglycerin (NG) would be exaggerated after 56 days of 6 degrees head-down bed rest (HDBR) in women, and that an aerobic and resistive exercise countermeasure (EX, n = 8) would ...
H. Edgell, J.K. Shoemaker, K.A. Zuj, M.A. Custaud, P. Arbeille, R.L. Hughson   +5 more
core   +3 more sources

Disrupted circadian rhythms and opioid‐mediated adverse effects: Bidirectional relationship and putative mechanisms

Journal of Neuroendocrinology, EarlyView.
Abstract Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid‐induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects.
Nasrin Mehranfard, Maedeh Ghasemi, Ehsan Saboory   +2 more
wiley   +1 more source

The Potential Synergistic Activity of Zolmitriptan Combined in New Self-Nanoemulsifying Drug Delivery Systems: ATR-FTIR Real-Time Fast Dissolution Monitoring and Pharmacodynamic Assessment

International Journal of Nanomedicine, 2021
Shady M Abd El-Halim,1 Mohamed A Mamdouh,1 Sherif M Eid,2 Bassant MM Ibrahim,3 Dina A Aly Labib,4 Sara M Soliman1 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza, 12585, Egypt ...
Abd El-Halim SM, Mamdouh MA, Eid SM, Ibrahim BMM, Aly Labib DA, Soliman SM   +5 more
doaj  

A COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF ANTIANGINAL DRUGS OF DIFFERENT GROUPS — NITROVASODILATATOR (ISOSORBIDE-5-MONONITRATE SUSTAINED RELEASE) AND BETA-BLOCKER WITH VASODILATING ACTION (NEBIVOLOL) — IN PATIENTS WITH STABLE ANGINA

Рациональная фармакотерапия в кардиологии, 2016
Aim. To compare the efficacy and safety of the slow-release isosorbide-5-mononitrate and of the nebivolol in patients with stable angina. Material and Methods.
S. Yu. Martsevich, N. P. Kutishenko, V. A. Egorov, A. V. Zagrebel'nyy, A. A. Serazhim, Yu. V. Lukina, N. A. Dmitrieva   +6 more
doaj   +1 more source

The nitrite anion: the key intermediate in alkyl nitrates degradative mechanism. [PDF]

, 2007
Alkyl nitrates, _in vivo_, are metabolized to yield nitric oxide, and thiol groups are considered necessary cofactors. This statement is based on studies that underline how these species potentiate hemodynamic responsiveness to nitrates in patients with ...
Loris Grossi
core   +1 more source

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]

, 2018
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon, Baca, Serapio M, Waschek, James A   +2 more
core   +2 more sources