Results 231 to 240 of about 2,974,752 (361)

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +13 more
wiley   +1 more source

Chronic Nitrous Oxide Toxicity Despite Elevated Serum Vitamin B₁₂ Level: A Case Report. [PDF]

Clin Pract Cases Emerg Med
Graves J, Hafner J.
europepmc   +1 more source

Probing the Challenge of P‐Type Semiconductors in Long‐Chain VOC Detection: 3D Micro‐Flower Zinc Cobaltate Heterojunction Sensors

Advanced Science, EarlyView.
Fe@WO3/ZnCo2O4 n‐p heterojunction sensor exhibits excellent room‐temperature sensing toward tetradecane, with a low detection limit of 78.4 ppb and short recovery time. The good performance is attributed to synergistic effects from heterojunctions, heteroatom doping, oxygen vacancies, high‐energy facets, and theoretical validations.
Kewei Liu, Zichen Zheng, Yiwen Zhou, Carla Bittencourt, Marc Debliquy, Chao Zhang   +5 more
wiley   +1 more source

Evaluation of dental treatments under nitrous oxide-oxygen inhalation sedation in pediatric patients with dental anxiety: a 10-Year retrospective study. [PDF]

BMC Oral Health
Ghabchi B, Önçağ Ö, Arabulan S, Aşık A, Uzel İ.   +4 more
europepmc   +1 more source

Nitrous oxide production by nitrification and denitrification in the Eastern Tropical South Pacific oxygen minimum zone

, 2015
Q. Ji, A. R. Babbin, A. Jayakumar, S. Oleynik, B. Ward   +4 more
semanticscholar   +1 more source

Stacking Interventions Enhances Carbon Removals and Profitability of Livestock Production Systems

Advanced Science, EarlyView.
The study indicates that stacking multiple interventions aimed at maximising soil organic carbon (SOC) sequestration and enteric methane (CH4) reductions realizes greater abatement and profit do any singular intervention, especially when SOC sequestration accounts for a significant proportion of greenhouse gas emissions (GHG) mitigation. Abstract While
My Pham‐Kieu, Stephen Ives, Warwick Badgery, Matthew Tom Harrison   +3 more
wiley   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

Neurological disorders caused by recreational use of nitrous oxide-a retrospective study from a German metropolitan area and review of the literature. [PDF]

Neurol Res Pract
Tshagharyan A, You SJ, Grefkes C, Hattingen E, Steinbach JP, Zeiner PS, Hildner M, Divé I.   +7 more
europepmc   +1 more source