Results 241 to 250 of about 2,974,752 (361)

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know? [PDF]

Addiction
Brunt TM, van den Brink W, van Amsterdam J.   +2 more
europepmc   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Nitrous oxide as diazo transfer reagent. [PDF]

Chem Sci
Genoux A, Severin K.
europepmc   +1 more source

Mucociliary Clearance Inspired Nanozyme‐centric Hydrogel Composites for Integrated Bacterial Detection

Advanced Science, EarlyView.
Inspired by human pulmonary cilia and their mucus defend against bacteria, nanozyme‐centric hydrogel networks have been assembled into nanowires, combining the rapid penetration capability of the nanowire arrays with the adhesion and detection functions of the nanozyme‐centric hydrogel networks.
Zhaoling Tan, Xuejiao Wang, Zhaoyue Wang, Jieke Jiang, Xi Yao   +4 more
wiley   +1 more source

The binding sites of carbon dioxide, nitrous oxide, and xenon reveal a putative exhaust channel for bovine cytochrome c oxidase. [PDF]

J Biol Chem
Muramoto K, Ide T, Shinzawa-Itoh K.
europepmc   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Nitrous Oxide Causing Subacute Combined Degeneration: A Case Report. [PDF]

Cureus
Thomas N, Patel R, Oluwadamilola B.
europepmc   +1 more source

Is Nitrous Oxide Anæsthetic? [PDF]

openalex   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source