Results 261 to 270 of about 2,953,686 (341)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

open access: yesAdvanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang   +12 more
wiley   +1 more source

Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. [PDF]

open access: yesNat Commun
Cichon J   +7 more
europepmc   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

open access: yesAdvanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan   +13 more
wiley   +1 more source

An Azide-Free Synthesis of Metallodiazomethanes Using Nitrous Oxide. [PDF]

open access: yesJ Am Chem Soc
Ward RJ   +6 more
europepmc   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

open access: yesAdvanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma   +5 more
wiley   +1 more source

TFT Backplanes Doped by BF2 Ion for Improved Stability and AMOLED Display Quality

open access: yesAdvanced Electronic Materials, EarlyView.
BF₂ ion in LTPS TFT induces an additional shallow defect level near the valence band edge, which is confirmed by deep‐level transient spectroscopy test. BF₂ in the poly Si functions as a donor, facilitating mutual compensation of defect charges within the TFT channel, and consequently, BF₂‐doped TFT channels exhibit a lower density of deep‐level traps,
Ying Shen   +8 more
wiley   +1 more source

Magnetically Compensated Nanometer‐Thin Ga‐Substituted Yttrium Iron Garnet (Ga:YIG) Films with Robust Perpendicular Magnetic Anisotropy

open access: yesAdvanced Electronic Materials, EarlyView.
This study reports on the remanent magnetization 4πMr and the temperature dependence of the net magnetization of magnetically compensated Ga:YIG films. For samples with very low net magnetic moments, the compensation points Tcomp and the Curie temperatures TC are determined. Ga:YIG films exhibit a significant increase in effective magnetization 4πMeff,
Carsten Dubs, Oleksii Surzhenko
wiley   +1 more source

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