Results 311 to 320 of about 300,840 (336)

Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme

Science, 2020
Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (
Shoucai Ma, D. Lapin, Li Liu, Yue Sun, Wen Song, Xiaoxiao Zhang, E. Logemann, Dongli Yu, Jia Wang, J. Jirschitzka, Zhifu Han, P. Schulze-Lefert, J. Parker, J. Chai   +13 more
semanticscholar   +1 more source

NLRs in plants

Current Opinion in Immunology, 2015
Intracellular immune receptors with nucleotide-binding, leucine-rich domains (NLRs) are found in both plants and animals. Compared to animals, NLR-encoding gene families are expanded, more prevalent and have enriched diversity in higher plants. Strong host defense triggered by the recognition of specific pathogen effectors constitutes a major part of ...
Xin Li, Paul Kapos, Yuelin Zhang
openaire   +2 more sources

The evolution of plant NLR immune receptors and downstream signal components.

Current opinion in plant biology, 2023
Along with the emergence of green plants on this planet one billion years ago, the nucleotide binding site leucine-rich repeat (NLR) gene family originated and diverged into at least three subclasses.
Yang Liu, Yan-mei Zhang, Yao Tang, Jian-Qun Chen, Zhu-Qing Shao   +4 more
semanticscholar   +1 more source

Staying vigilant: NLR monitors virus invasion

Trends in Plant Science, 2023
Phytohormones play important roles in plant immunity. Recently, Chen et al. discovered that the tomato spotted wilt virus attacks the plant hormone receptor to promote infection. Plants evolved an immune receptor to mimic the attacked hormone receptors to recognize the virus, thereby activating a robust immune response.
Jian Chen, Jianping Chen, Zongtao Sun
openaire   +2 more sources

NLR functions beyond pathogen recognition

Nature Immunology, 2011
The last 10 years have witnessed the identification of a new class of intracellular pattern-recognition molecules--the nucleotide-binding domain and leucine-rich repeat-containing family (NLR). Members of this family garnered interest as pattern-recognition receptors able to trigger inflammatory responses against pathogens.
Kufer, Thomas A, Sansonetti, Philippe J
openaire   +2 more sources

A single NLR gene confers resistance to leaf and stripe rust in wheat

Nature Communications
Nucleotide-binding leucine-rich repeat (NLR) disease resistance genes typically confer resistance against races of a single pathogen. Here, we report that Yr87/Lr85, an NLR gene from Aegilops sharonensis and Aegilops longissima, confers resistance ...
Davinder Sharma, Raz Avni, Juan J. Gutierrez-Gonzalez, Rakesh Kumar, Hanan Sela, M. R. Prusty, Arava Shatil-Cohen, István Molnár, K. Holušová, Mahmoud Said, J. Doležel, Eitan Millet, Sofia Khazan-Kost, Udi Landau, Gerit Bethke, O. Sharon, S. Ezrati, Moshe Ronen, Oxana Maatuk, T. Eilam, J. Manisterski, P. Ben-Yehuda, Y. Anikster, O. Matny, B. Steffenson, M. Mascher, Helen J. Brabham, M. Moscou, Yong Liang, Guotai Yu, B. Wulff, G. Muehlbauer, A. Minz-Dub, A. Sharon   +33 more
semanticscholar   +1 more source

The NLR-related disorders

Seminars in Immunopathology, 2007
The present issue, which is dedicated to the NOD-like receptors (NLRs), is particularly timely since there is burgeoning evidence that these molecules play a pivotal role in an expanding number of monogenic and polygenic disease. At the molecular level the NLR family of molecules plays a key role as pattern recognition receptors for intracellular ...
openaire   +2 more sources

Method to Measure Ubiquitination of NLRs

2023
Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here we describe a method to detect poly-ubiquitination of NRLP3 using two different approaches: (i) detection ...
Worboys, Jonathan D, Palazón-Riquelme, Pablo, López-Castejón, Gloria   +2 more
openaire   +4 more sources

Plant NLRs: From discovery to application

Plant Science, 2019
Plants require a complex immune system to defend themselves against a wide range of pathogens which threaten their growth and development. The nucleotide-binding leucine-rich repeat proteins (NLRs) are immune sensors that recognize effectors delivered by pathogens. The first NLR was cloned more than twenty years ago.
Paul, Kapos, Karen Thulasi, Devendrakumar, Xin, Li   +2 more
openaire   +2 more sources

Method to Measure Ubiquitination of NLRs

2016
Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here, we describe a method to detect polyubiquitination of NRLP3 using two different approaches: (1) detection ...
Palazón, Pablo, Lopez-Castejon, Gloria
openaire   +4 more sources