Results 191 to 200 of about 55,457 (295)

Benchmarking heterogeneous network-based methods for drug repurposing. [PDF]

NPJ Syst Biol Appl
Nguyen TT, Pawitan Y, Calza S, Vu TN.
europepmc   +1 more source

Neuromuscular fatigue and loss of torque complexity during severe‐intensity exercise: The role of muscle size

Experimental Physiology, Volume 111, Issue 5, Page 2588-2598, 1 May 2026.
Abstract This study investigated the effect of severe‐intensity exercise on neuromuscular fatigue (NMF) and torque complexity in two muscle groups of different sizes. The NMF of 11 healthy males was assessed through maximal voluntary contractions at the beginning, every minute and at task failure during intermittent isometric exercise performed at an ...
Rubens Correa Junior, Renan Vieira Barreto, Gabriel Fontanetti, Leonardo Coelho Rabello de Lima, Benedito Sérgio Denadai, Camila Coelho Greco   +5 more
wiley   +1 more source

The interpretable multimodal dimension reduction framework SpaHDmap enhances resolution in spatial transcriptomics. [PDF]

Nat Cell Biol
Tang J, Chen Z, Qian K, Huang S, He Y, Yin S, He X, Ye B, Zhuang Y, Meng H, Xi JJ, Xi R.   +11 more
europepmc   +1 more source

Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça, Donald Seanego, Christopher Jurisch, Melina Mottin, Flávia Nader Motta, Beatriz S. A. Rodrigues, Gilberto S. M. Junior, Alexandra Maria dos Santos Carvalho, Fábio Muniz de Oliveira, Sunniva Sigurdardóttir, Per Sunnerhagen, Izabela Marques Dourado Bastos, Richard Gessner, Kelly Chibale, Carolina Horta Andrade   +14 more
wiley   +1 more source

Robust Sparse Non-Negative Matrix Factorization for Identifying Signals of Interest in Bearing Fault Detection. [PDF]

Sensors (Basel)
Shiri H, Michalak A.
europepmc   +1 more source

Single-channel audio source separation with NMF: divergences, constraints and algorithms

, 2018
C. Févotte, E. Vincent, A. Ozerov
semanticscholar   +1 more source

Integrated multi-omics analysis reveals comprehensive metabolism-driven tumor heterogeneity and immune microenvironment in hepatocellular carcinomas. [PDF]

Sci Rep
Li Y, Luo Z, Zhang B, Zhu W, Zhang J, Li Z, Zhang L.   +6 more
europepmc   +1 more source

Non-negative matrix factorization and deconvolution as a dual simplex problem. [PDF]

Genome Biol
Kleverov D, Aladyeva E, Serdyukov A, Artyomov MN.   +3 more
europepmc   +1 more source

FinTextSim: a domain-specific sentence-transformer for extracting predictive latent topics from financial disclosures. [PDF]

Front Artif Intell
Jehnen S, Villalba-Díez J, Ordieres-Meré J.   +2 more
europepmc   +1 more source

Nonnegative matrix factorization incorporating domain specific constraints for four dimensional scanning transmission electron microscopy. [PDF]

Sci Rep
Kimoto K, Uesugi F, Harano K, Kikkawa J, Cretu O, Shibazaki Y, Shiga M, Togo A.   +7 more
europepmc   +1 more source