Results 191 to 200 of about 1,434,331 (312)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Solvent-Selective Complexity Reduction of Effluent Dissolved Organic Matter for ¹H NMR Spectroscopy. [PDF]

Anal Chem
Shakeri Yekta S, Enrich Prast A, Hedenström M, Sparrman T, Šafarič L, Carraro G, Oliveira HR, Anacleto TM, Björn A, Hertkorn N.   +9 more
europepmc   +1 more source

GPCRs: Lock and key become flexible [PDF]

, 2018
Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy   +2 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Continuous-Wave (CW) Photo-CIDNP NMR Spectroscopy: A Tutorial. [PDF]

Magn Reson Chem
Kuhn LT, Pérez-Trujillo M.
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Middle-aged rat hippocampus and some early changes accompanying aging

Open Life Sciences, 2012
Gasparova Zdenka, Janega Pavol, Pronayova Nada, Liptaj Tibor   +3 more
doaj   +1 more source

Automated Chemical Profiling of Wine by Solution NMR Spectroscopy: A Demonstration for Outreach and Education. [PDF]

J Chem Educ
Capeci L, Jia R, Peek ME, Simma MK, Corbin EA, Vidya FNU, Wu H, Leisen JE, McShan AC.   +8 more
europepmc   +1 more source

A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems

Advanced Science, EarlyView.
Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li, Corin T. Scott, Taku Suzuki‐Osborne, John P. Lowe, Dominic Taylor, Mariolino Carta, Neil B. McKeown, Andrew D. Burrows, Lucia H. Mascaro, Frank Marken   +9 more
wiley   +1 more source

Quantifying the Biodegradation of Water-Soluble Polymer Mixtures with Diffusion NMR Spectroscopy. [PDF]

Angew Chem Int Ed Engl
Brenninkmeijer LT, Golding JL, Brandolese A, Britton MM, Dove AP.   +4 more
europepmc   +1 more source