Results 21 to 30 of about 159,141 (247)

Bortezomib Combination Therapy of Relapsed and Refractory Acute Lymphoblastic Leukemia in Children

Клиническая онкогематология, 2017
Background & Aims. Despite significant success in the treatment of acute lymphoblastic leukemia (ALL) in children, relapses and drug resistance to the standard therapy remain the main cause of treatment failure.
Natal’ya Andreevna Batmanova, M. A. Shervashidze, A. V. Popa, L. Yu. Grivtsova, I. N. Serebryakova, G. L. Mentkevich   +5 more
doaj   +1 more source

Modified combined radiotherapy for cervical cancer in kidney transplant recipient

Clinical Case Reports, 2021
The management of locally advanced cervical cancer in patients with a pelvic kidney transplant is challenging because standard chemoradiotherapy may increase the risk of ureteral stenosis and obstruction or vascular damage of the graft. In the absence of
Olga P.Matylevich, Aleksander B.Shushkevich, Valentina A.Suslova, Pavel A.Perevoschikov, Siarhei A.Mavrichev   +4 more
doaj   +1 more source

Generalization of Neural Networks on Second-Order Hypercomplex Numbers

Mathematics, 2023
The vast majority of existing neural networks operate by rules set within the algebra of real numbers. However, as theoretical understanding of the fundamentals of neural networks and their practical applications grow stronger, new problems arise, which ...
Stanislav Pavlov, Dmitry Kozlov, Mikhail Bakulin, Aleksandr Zuev, Andrey Latyshev, Alexander Beliaev   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

PREDICTION INDONESIA COMPOSITE INDEX USING INTEGRATION DECOMPOSITION- NEURAL NETWORK ENSEMBLE DURING VUCA ERA

Barekeng
The Volatility, Uncertainty, Complexity, and Ambiguity (VUCA) era causes turmoil in the capital markets, stocks, commodities, etc. The impact is a decline in the Composite Stock Price Index (IHSG) in 2020.
Imelda Saluza, Ensiwi Munarsih, Faradillah Faradillah, Leriza Desitama Anggraini   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

THE SIGNIFICANCE OF IMMUNOMODULATORY THERAPY IN PREGRAVIDAL PREPARATION OF THE PATIENTS WITH RECURRENT HSV TYPE 2

Акушерство, гинекология и репродукция, 2016
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) - is a widespread viruses that can form a lifelong infection and persistence. Genital herpes in women of childbearing age is a serious risk of vertical transmission from mother to fetus.
N. N. Minaev, D. Ju. Bugrimov, A. A. Klimovich   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Diagnosis of Acute Lymphoblastic Leukemia Originating From T-Lineage Precursors and Approaches to Minimal Residual Disease Monitoring

Клиническая онкогематология, 2019
Background. Minimal residual disease (MRD) is an independent prognostic factor in acute lymphoblastic leukemia (ALL) in children. The immunological assessment of MRD cell count is based on aberrant immunophenotype of tumor lymphoblasts.
Ol’ga Alekseevna Chernysheva, L. Yu. Grivtsova, I. N. Serebryakova, N. A. Kupryshina, E. N. Sholokhova, M. A. Shervashidze, A. D. Palladina, B. V. Kurdyukov, A. V. Popa, N. N. Tupitsyn   +9 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source