Results 231 to 240 of about 7,591,877 (308)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Hybrid sequencing reveals incompleteness of the H37Rv reference genome and highlights lineage-specific genomic divergence in <i>Mycobacterium tuberculosis</i>. [PDF]

Microb Genom
Chen H, Li X, Chen R, Zhang M, Zhu Y, Wu K, Lu Y, Wang X, Che Y, Liu Z.   +9 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Verification of harmonized reference intervals in Croatia: is it time for a change? [PDF]

Biochem Med (Zagreb)
Friščić I, Burazer I, Radeljak A, Perkov S, Kardum Paro MM.   +4 more
europepmc   +1 more source

Angiotensin inhibitors during neoadjuvant chemotherapy improve esophageal squamous cell carcinoma outcomes. [PDF]

Ther Adv Med Oncol
Chen M, Huang Y, Liu F, Lin C, Zhang S, Zeng T, Yu J, Zheng B, Chen C.   +8 more
europepmc   +1 more source

Preoperative PNI-dNLR Score as Predicting Long-Term Survival in Older Adults Undergoing Radical Gastrectomy for Gastric Cancer. [PDF]

Clin Interv Aging
Chen XL, Zhang XM, Lin ZX, Huang XL, Chen YZ, Lin WZ, Zheng CY, Lin W.   +7 more
europepmc   +1 more source

Comparative bioequivalence of 1 mg and 4 mg tacrolimus extended-release tablets: randomized, open label, fully replicate, crossover trials in healthy adult subjects. [PDF]

Front Nephrol
Sharma JK, Bunger D, Zaveri H, Chaturvedi A.   +3 more
europepmc   +1 more source