Results 111 to 120 of about 26,370,447 (260)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reference Notes (November 2002)

open access: yes, 2002
Table of Contents includes: Virtual Reference Services; Minitex Goes to School(s); The Changing Face of Reference; Information Bits.Minitex Reference Outreach & Instruction. (2002). Reference Notes (November 2002).
Minitex Reference Outreach & Instruction
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Reference Notes (January 2003)

open access: yes, 2003
Table of Contents includes: Virtual Reference Services Part 3: Issues in Virtual Reference; Google Enhancements; Information Bits.Minitex Reference Outreach & Instruction. (2003). Reference Notes (January 2003).
Minitex Reference Outreach & Instruction
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Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Effects of glycine 64 substitutions in RNA-dependent RNA polymerase on ribavirin sensitivity and pathogenicity of coxsackievirus A6

open access: yesVirus Research
Hand, foot, and mouth disease (HFMD) caused by a group of enteroviruses is a global public health problem. In recent years, coxsackievirus A6 (CVA6) has emerged as an important HFMD agent.
Rui Wang   +11 more
doaj   +1 more source

Professional Competencies for Reference and User Services Librarians Version 2017

open access: yes, 2017
As the professional organization for reference and user services, the Reference and Users Services Association (RUSA) has developed and updated a model statement of competencies essential for successful reference and user services ...
RUSA Professional Competencies for Reference and User Services Librarians Task Force
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Measuring and Assessing Reference Services and Resources: A Guide Version 2008

open access: yes, 2008
Measuring and Assessing Reference Services and Resources: A Guide offers an expansive definition of reference service, assessment planning advice, and measurement tools to assist managers in evaluating reference services and resources.
RUSA/RSS Evaluation of Reference and User Services Committee
core  

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