Results 131 to 140 of about 230,825 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

No‐reference image quality assessment via a dual‐branch residual network

open access: yesIET Image Processing
The No‐Reference Image Quality Assessment (NR‐IQA) method can predict quality scores of distorted images without the reference image. However, due to the variability in both color and structure of images, existing NR‐IQA methods struggle to accurately ...
Peng Ji, Chang Liu, Hao Chen
doaj   +1 more source

A No-Reference Image Quality Assessment Based on Property of the Human Visual

open access: yes, 2011
This paper produced for the distortion caused by the edge bluring in the image inpainted, proposing a novel no-reference quality assessment based on the human visual property. Using visual sensitivity function CFS which descripes the properties for human
Li Guo Wang
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Designing a Cockpit for Image Quality Evaluation [PDF]

open access: yes, 2019
Image Quality (IQ) as assessed by humans is a concept hard to be defined, since it relies on many different features, including both low level and high level visual characteristics.
Michela Lecca   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Less is More: Learning Reference Knowledge Using No-Reference Image Quality Assessment

open access: yes, 2023
Image Quality Assessment (IQA) with reference images have achieved great success by imitating the human vision system, in which the image quality is effectively assessed by comparing the query image with its pristine reference image.
Ji, Rongrong   +11 more
core  

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