Results 41 to 50 of about 19,323,977 (168)

No dose–no poison [PDF]

Environmental Health and Preventive Medicine, 2012
Environmental scientists attempt to find a causal connection between pollutants and disease, especially cancer. For most environmental exposures, however, the dose is too low to detect an effect. Only exposure to high doses of chemical substances can be shown to increase the risk for cancer, as is evident by examining the list of definite human ...
openaire   +2 more sources

Polyamines: pleiotropic molecules regulating plant development and enhancing crop yield and quality

Plant Biotechnology Journal, Volume 22, Issue 11, Page 3194-3201, November 2024.
Summary Polyamines (PAs) are pleiotropic bioorganic molecules. Cellular PA contents are determined by a balance between PA synthesis and degradation. PAs have been extensively demonstrated to play vital roles in the modulation of plant developmental processes and adaptation to various environmental stresses.
Haishan Yang, Yinyin Fang, Zhiman Liang, Tian Qin, Ji‐Hong Liu, Taibo Liu   +5 more
wiley   +1 more source

The effects of simvastatin‐loaded nanoliposomes on human multilineage liver fibrosis microtissue

Journal of Cellular and Molecular Medicine, Volume 28, Issue 13, July 2024.
Abstract In this in vitro study, for the first time, we evaluate the effects of simvastatin‐loaded liposome nanoparticles (SIM‐LipoNPs) treatment on fibrosis‐induced liver microtissues, as simvastatin (SIM) has shown potential benefits in the non‐alcoholic fatty liver disease process.
Shima Parsa, Maryam Dousti, Nasim Mohammadi, Mozhgan Abedanzadeh, Niloofar Dehdari Ebrahimi, Mahintaj Dara, Mahsa Sani, Muhammad Nekouee, Samira Sadat Abolmaali, Farnaz Sani, Negar Azarpira   +10 more
wiley   +1 more source

Exploring rat corpus cavernosum alterations induced by finasteride treatment and withdrawal

Andrology, Volume 12, Issue 3, Page 674-681, March 2024.
Abstract Despite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5α‐reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These side effects may persist after drug suspension, inducing the so‐
Silvia Diviccaro, Monika Herian, Lucia Cioffi, Matteo Audano, Nico Mitro, Donatella Caruso, Silvia Giatti, Roberto Cosimo Melcangi   +7 more
wiley   +1 more source

Biochemical insights into the anthelmintic and anti-inflammatory potential of sea cucumber extract: In vitro and in silico approaches

Open Chemistry
Helminthiasis is a global parasitic disease, and current anthelmintics like albendazole are costly, toxic, and increasingly ineffective due to resistance.
Thagfan Felwa A., El-Sayed Youssef A., Abdel-Moneim Ahmed, Abdel-Gaber Rewaida, Mubaraki Murad A., Dkhil Mohamed A., Taha Rania G.   +6 more
doaj   +1 more source

Exogenous application of pectin triggers stomatal closure and immunity in Arabidopsis

Molecular Plant Pathology, Volume 25, Issue 2, February 2024.
Exogenous pectin enhanced immunity to Pseudomonas syringae pv. tomato DC3000 in Arabidopsis, along with stomatal closure, mitogen‐activated protein kinases activation, and defence‐responsive genes’ expression. Abstract Pectin has been extensively studied in animal immunity, and exogenous pectin as a food additive can provide protection against ...
Cheng Zhang, Charles Tetteh, Sheng Luo, Pinyuan Jin, Xingqian Hao, Min Sun, Nan Fang, Yingjun Liu, Huajian Zhang   +8 more
wiley   +1 more source

Gaseous mediators (H2S, NO and CO) a new approach in gastrointestinal protection

Mexican Journal of Medical Research ICSA, 2023
Gastrointestinal damage is generated by a wide range of harmful agents, and is the result of the activation of inflammatory, oxidant and cytotoxic mechanisms, that together overwhelm the “mucosa defense” of the gastrointestinal (GI) tract.
Elizabeth Arlen Pineda-Peña, Aracely Evangelina Chávez-Piña   +1 more
doaj   +1 more source

Enhancing Inflammatory Factors, Nitric Oxide, and Arterial Stiffness Through Aquatic Walking for Amelioration and Disease Prevention: Targeting in Obese Elderly Women

Mediators of Inflammation, Volume 2024, Issue 1, 2024.
In elderly women, hormonal changes lead to elevated body fat content, which results in elevated levels of vascular inflammatory factors, thereby increasing the risk of cardiovascular diseases (CVDs) associated with endothelial dysfunction. Regular physical exercises tend to keep these in check and are protective to the body.
Woo-Hyeon Son, Woo-Min Jeong, In Young Park, Min-Seong Ha, Elena Niccolai   +4 more
wiley   +1 more source

Numerical study on the physics of flow past submerged vane in curved channel and curved channel whit lateral intake [PDF]

مهندسی منابع آب, 2020
In this paper, the physics of passed flow on submerged vane that placed at the bottom of different kinds of channels is studied. Also it presente the effects of: changing angle’s vane, the distance of vane from wall and the situation of vane in front of ...
fatemeh avazpoor, keivan tavakoli, hosein montaseri   +2 more
doaj  

Different alterations of cerebral regional homogeneity in early-onset and late-onset Parkinson's disease

Frontiers in Aging Neuroscience, 2016
Objective: Early-onset Parkinson’s disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective is to investigate whether characteristics of spontaneous brain activity in the resting
Ke Sheng, Weidong Fang, Yingcheng Zhu, Guangying Shuai, Dezhi Zou, Meilan Su, Yu Han, Oumei Cheng   +7 more
doaj   +1 more source