Results 41 to 50 of about 34,721,811 (217)

Leukocyte Platelet‐Rich Plasma‐Derived Exosomes Restrained Macrophages Viability and Induced Apoptosis, NO Generation, and M1 Polarization

Immunity, Inflammation and Disease, Volume 12, Issue 11, November 2024.
Exosomes from L‐PRP restrained viability, induced apoptosis and NO generation of macrophages, and promoted M1 polarization, while exosomes from P‐PRP increased M2 polarization. The exosomes from L‐PRP presented a more effective effect on macrophages than that from P‐PRP, making it a promising strategy for chronic refractory wound management.
Xiong Li, Feifei Guo, Jiehua Deng, Jiasong Li, Jie Zhang, Ming Fu, Hui Fan   +6 more
wiley   +1 more source

Aloe Extracts Inhibit Skin Inflammatory Responses by Regulating NF-κB, ERK, and JNK Signaling Pathways in an LPS-Induced RAW264.7 Macrophages Model

Clinical, Cosmetic and Investigational Dermatology, 2023
Fei Wang,1– 3,* Jitao Liu,1– 3 Quan An,1– 4,* Yiming Wang,1– 3 Yang Yang,1– 3 Tong Huo,1– 3 Simin Yang,5 Ruijun Ju,5 Qianghua Quan1– 4 1Research and Development Department, Yunnan Baiyao Group Health Products Co., Ltd., Kunming, People’s Republic
Wang F, Liu J, An Q, Wang Y, Yang Y, Huo T, Yang S, Ju R, Quan Q   +8 more
doaj  

Effect of CFP-10/ESAT-6 secretory proteins on long-term non-specific immunological memory in mouse macrophages

Медицинская иммунология, 2023
Innate immune cells (monocytes/macrophages, NK) can also develop immune memory, which means that these cells are trained after their first encounter with pathogens so that they exhibit a nonspecific immunological response to the same or another pathogen.
А. P. Lykov, S. N. Belogorodtsev, Е. К. Nemkova, А. Vetlugina, Т. М. Terekhova, Ya. Sh. Schwartz   +5 more
doaj   +1 more source

Soluble GC stimulators and activators: Past, present and future

British Journal of Pharmacology, Volume 181, Issue 21, Page 4130-4151, November 2024.
The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to elucidate NO–sGC signalling and opened novel pharmacological opportunities for cardiovascular indications and beyond. The first‐in‐class sGC stimulator riociguat was approved for pulmonary hypertension in 2013 and vericiguat very recently for heart failure.
Peter Sandner, Markus Follmann, Eva Becker‐Pelster, Michael G. Hahn, Christian Meier, Cecilia Freitas, Lothar Roessig, Johannes‐Peter Stasch   +7 more
wiley   +1 more source

Polyamines: pleiotropic molecules regulating plant development and enhancing crop yield and quality

Plant Biotechnology Journal, Volume 22, Issue 11, Page 3194-3201, November 2024.
Summary Polyamines (PAs) are pleiotropic bioorganic molecules. Cellular PA contents are determined by a balance between PA synthesis and degradation. PAs have been extensively demonstrated to play vital roles in the modulation of plant developmental processes and adaptation to various environmental stresses.
Haishan Yang, Yinyin Fang, Zhiman Liang, Tian Qin, Ji‐Hong Liu, Taibo Liu   +5 more
wiley   +1 more source

The effects of simvastatin‐loaded nanoliposomes on human multilineage liver fibrosis microtissue

Journal of Cellular and Molecular Medicine, Volume 28, Issue 13, July 2024.
Abstract In this in vitro study, for the first time, we evaluate the effects of simvastatin‐loaded liposome nanoparticles (SIM‐LipoNPs) treatment on fibrosis‐induced liver microtissues, as simvastatin (SIM) has shown potential benefits in the non‐alcoholic fatty liver disease process.
Shima Parsa, Maryam Dousti, Nasim Mohammadi, Mozhgan Abedanzadeh, Niloofar Dehdari Ebrahimi, Mahintaj Dara, Mahsa Sani, Muhammad Nekouee, Samira Sadat Abolmaali, Farnaz Sani, Negar Azarpira   +10 more
wiley   +1 more source

Intonation, yes and no

Glossa, 2018
English polar particles yes and no are interchangeable in response to negative sentences, that is, either one can be used to convey both positive and negative responses.
Daniel Goodhue, Michael Wagner
doaj   +2 more sources

Correlación entre diferentes contaminantes atmosféricos de la Ciudad de México y el Área Metropolitana

Ciencia Ergo Sum, 2020
Se lleva a cabo un estudio de correlación estadística entre datos numéricos correspondientes a la concentración de las partículas suspendidas y a la concentración de gases contaminantes que son obtenidos de las mediciones registradas en la base de datos ...
Israel Gutiérrez González, Dora María Calderón Nepamuceno, Doricela Gutierrez Cruz, Eduardo Aquino Verga   +3 more
doaj   +1 more source

Exploring rat corpus cavernosum alterations induced by finasteride treatment and withdrawal

Andrology, Volume 12, Issue 3, Page 674-681, March 2024.
Abstract Despite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5α‐reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These side effects may persist after drug suspension, inducing the so‐
Silvia Diviccaro, Monika Herian, Lucia Cioffi, Matteo Audano, Nico Mitro, Donatella Caruso, Silvia Giatti, Roberto Cosimo Melcangi   +7 more
wiley   +1 more source

Exogenous application of pectin triggers stomatal closure and immunity in Arabidopsis

Molecular Plant Pathology, Volume 25, Issue 2, February 2024.
Exogenous pectin enhanced immunity to Pseudomonas syringae pv. tomato DC3000 in Arabidopsis, along with stomatal closure, mitogen‐activated protein kinases activation, and defence‐responsive genes’ expression. Abstract Pectin has been extensively studied in animal immunity, and exogenous pectin as a food additive can provide protection against ...
Cheng Zhang, Charles Tetteh, Sheng Luo, Pinyuan Jin, Xingqian Hao, Min Sun, Nan Fang, Yingjun Liu, Huajian Zhang   +8 more
wiley   +1 more source