Results 171 to 180 of about 2,815,445 (292)

Efficient Red Light‐Driven Singlet Oxygen Photocatalysis with an Osmium‐Based Coulombic Dyad

open access: yesAngewandte Chemie International Edition, Accepted Article.
Photoactive osmium complexes are widely used sensitizers for the generation of singlet oxygen, because they can be excited directly into their triplet states with low‐energy red light. However, their short‐lived excited states reduce quenching efficiencies and reaction quantum yields significantly.
Matthias Schmitz   +3 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Building a Bridge Between Ambient MS and LC‐MS by Non‐Exhaustive Microdesorption

open access: yesAngewandte Chemie International Edition, Accepted Article.
Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects and limited selectivity. The absence of a separation step can also lead to false positives due to the isomers or isobars.
Wei Zhou, Janusz Pawliszyn
wiley   +1 more source

Photo‐controlled Release of Urea Enables the Detection of Urea‐Urease Intermediates by cryo‐FTIR

open access: yesAngewandte Chemie International Edition, Accepted Article.
Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme.
Caterina Netto   +7 more
wiley   +1 more source

Glycosylation‐dependent Stability of Human Pentraxin‐2 Revealed by Surface‐Induced Dissociation and Ion Mobility Mass Spectrometry

open access: yesAngewandte Chemie International Edition, Accepted Article.
Pentraxin‐2 (PTX‐2), also known as Serum Amyloid P component, functions as an immunoregulatory glycoprotein and plays a crucial role in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). Desialylation of PTX‐2 has recently been associated with reduced bioactivity and diminished inhibition of fibrocyte differentiation in IPF patients.
Philipp Bittner   +7 more
wiley   +1 more source

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