Results 181 to 190 of about 2,815,445 (292)

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li, Hong-Rui Zhang, Yang Yang, Ben Chi-Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing-Cheung Chan, Karen Ka-Yan Kung, Qian Zhao   +10 more
wiley   +1 more source

Bibliometric insights into the cell cycle, aging, and metabolism: from molecular mechanisms to clinical implications. [PDF]

Biogerontology
Pan Y, Liu H, Chen J, Deng H, Yang C, Huang Y, Cai Q, Huang W, Huang M, Xiong S, Liu H, Huang L, Huang H, Liang W, He J.   +14 more
europepmc   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

Angewandte Chemie International Edition, Accepted Article.
Single‐molecule protein profiling offers unparalleled sensitivity for detecting rare biomarkers, with significant potential for early disease diagnosis and monitoring. Nanopore sensors enable the detection of proteins in solution and are well‐suited for clinical applications due to their high sensitivity and throughput.
Aleksandar Ivanov, Xiaoyi Wang, Yaxian Liu, Ren Ren, Joshua B. Edel   +4 more
wiley   +1 more source

Angularly Resolved Tip‐Enhanced Raman Spectroscopy

Angewandte Chemie International Edition, Accepted Article.
Despite intensive research in tip‐enhanced Raman spectroscopy (TERS), the angular distribution of Raman scattering in the TERS gap remains experimentally unreported leaving its relevance to the TERS signal formation to be seldomly discussed. Here, we investigate the angular distribution of the tip‐enhanced Raman signal in the Fourier plane using a ...
Felix Schneider, Tim Parker, Liangxuan Wang, Michel Rebmann, Yang Zhao, Eric Juriatti, Heiko Peisert, Alfred J. Meixner, Johannes Gierschner, Lingyan Meng, Dai Zhang   +10 more
wiley   +1 more source

Total Synthesis and Structural Revision of (‐)‐Sodagnitin E

Angewandte Chemie International Edition, Accepted Article.
We report the total synthesis of malabaricane triterpene sodagnitin E, marking the first synthesis of any malabaricane natural product to date. The enantioselective synthesis of two key fragments, followed by their coupling via a Mukaiyama aldol reaction delivered the triterpene framework in a convergent synthesis.
Philipp Schoch, Tanja Gaich
wiley   +1 more source

High‐Pressure Synthesis of Crystalline double‐layer Carbon Nitride Networks Stabilized in Bi7C10N18(N3(1‐ x )O3 x )

Angewandte Chemie International Edition, Accepted Article.
Application of high‐pressure conditions in chemical synthesis has proven to access a wide range of novel nitrogen‐rich compounds and to overcome the stability of the dinitrogen molecule. In the present work, we report the high‐pressure high‐temperature (HPHT) synthesis of Bi7C10N18(N3(1‐x)O3x), which features double‐layers of poly‐N‐(1,3,5‐triazin‐2‐yl)
Lukas Brüning, Nityasagar Jena, Pascal L. Jurzick, Elena Bykova, Nico Giordano, Mohamed Mezouar, Igor A. Abrikosov, Maxim Bykov   +7 more
wiley   +1 more source

Tracking 35 years of progress in metallic materials for extreme environments via text mining. [PDF]

Sci Rep
Wang X, Raj A, Su Y, Xu S, Lu K.
europepmc   +1 more source

Predicting A‐Element Substitution and MXene Formation in Reactions Between MAX Phases and Molten Salts

Angewandte Chemie International Edition, Accepted Article.
Selective etching has emerged as a key method for synthesizing 2D materials, with the conversion of MAX phases to MXenes being by far the most widely studied and reported example. While traditional methods rely on etching in primarily acidic aqueous media, molten salts offer an intriguing alternative.
Jonas Björk, Johanna Rosen
wiley   +1 more source

Evolution of documents related to performance in boccia: a paralympic sport bibliometric analysis. [PDF]

Front Sports Act Living
Ferreira CC, Hernández-Beltrán V, Gamonales JM, Espada MC, Muñoz-Jiménez J.   +4 more
europepmc   +1 more source

Photoresponsive slide‐ring gels enable modulation of sliding dynamics

Angewandte Chemie International Edition, Accepted Article.
Cyclodextrin‐based slide‐ring gels (SRG) have emerged as a promising class of materials owing to their unique topology. Upon mechanical loading, the slidable cross‐links of the polymer network freely translocate along the polymer backbone enabling pronounced energy dissipation in the material, which is associated with exceptional ductility and ...
Dalila Cafagno, Serena Silvi, Mark W. Tibbitt, Stefan Mommer   +3 more
wiley   +1 more source