Results 241 to 250 of about 2,815,445 (292)

Macromolecule‐Driven Supramolecular Polymerization Induced by Crowding Effects

open access: yesAngewandte Chemie International Edition, Accepted Article.
Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored. Here, we systematically investigate how excluded volume effects influence supramolecular polymerizations in organic media.
Joost van der Tol   +5 more
wiley   +1 more source

A fluorescent MTP‐based Detection Platform for Hydrogen Peroxide, Glucose, and Lactate

open access: yesAnalysis &Sensing, Accepted Article.
Hydrogen Peroxide (H2O2) is an important small metabolite often quantified with commercially available multi‐step fluorescence‐based assays. We developed a new microtiter plate (MTP) based platform that allows a rapid, one‐step assay with a ratiometric readout function.
John J. Galligan   +2 more
wiley   +1 more source

Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis. [PDF]

open access: yesJ Taibah Univ Med Sci
Muthmainah M   +5 more
europepmc   +1 more source

Analysis of plant metabolomics data using identification‐free approaches

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Plant metabolomes are structurally diverse. One of the most popular techniques for sampling this diversity is liquid chromatography–mass spectrometry (LC‐MS), which typically detects thousands of peaks from single organ extracts, many representing true metabolites.
Xinyu Yuan   +2 more
wiley   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun   +19 more
wiley   +1 more source

Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Despite availability of biologics and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit   +13 more
wiley   +1 more source

The FAIIR conversational AI agent assistant for youth mental health service provision. [PDF]

open access: yesNPJ Digit Med
Obadinma S   +9 more
europepmc   +1 more source

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