Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Three New Calcium Formate Reference Materials for δ<sup>13</sup>C Measurements and a Redetermination of the R(<sup>13</sup>C/<sup>12</sup>C) Ratio for VPDB Based on Proton Nuclear Magnetic Resonance Measurements. [PDF]
Hoffman DW +5 more
europepmc +1 more source
References of references in Robotics. References of references in manipulation.
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Genetic variability of immune checkpoints in asbestos-related diseases. [PDF]
Zeljkovic I +5 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Subjective and Objective Quality Assessment of Image: A Survey
With the increasing demand for image-based applications, the efficient and reliable evaluation of image quality has increased in importance. Measuring the image quality is of fundamental importance for numerous image processing applications, where the ...
Pedram Mohammadi +2 more
doaj
Author Correction: Performance enhancement of electrochemical discharge micromachining of borosilicate glass using nitrogen gas assistance. [PDF]
Tamilperuvalathan S +5 more
europepmc +1 more source
References of references in Robotics. References of references in geometric algorithms.
openaire +2 more sources

