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Placebo's invisible brother: a restricted scoping review of biomedical literature on the nocebo effect.

Pain, 2022
Placebos and their beneficial clinical and psychological effects are well-researched, but nocebo effects receive far less attention, despite being highly undesirable.
Owen Sweeney   +6 more
semanticscholar   +1 more source

Examining the Nocebo Effect in Trials of Neuromodulators for Use in Disorders of Gut-Brain Interaction

American Journal of Gastroenterology, 2022
INTRODUCTION: Nocebo effects are believed to influence the rate of reported adverse events (AE) and subject withdrawal in both the treatment and placebo groups of randomized clinical trials (RCT).
Jeremy R. Glissen Brown   +6 more
semanticscholar   +1 more source

Nocebo and lessebo effects

2020
The power of placebos is commonly associated with the placebo effect. In contrast, detrimental effects related to the use of a placebo are little studied and less well recognized. This chapter covers the nocebo and lessebo effects defined, respectively, as expectation of harm in the form of adverse events in a placebo arm and reduction of therapeutic ...
openaire   +2 more sources

Nocebo Effect on Pain Perception and Attention with Children With and Without Attention Deficit And/Or Hyperactivity Disorder.

Journal of Developmental and Behavioral Pediatrics
OBJECTIVE Attention deficit disorder with or without hyperactivity (ADHD) has negative consequences for children. The effectiveness of medical interventions and educational outcomes are strongly influenced by expectations, which can be modulated by ...
Carmen-Édith Belleï-Rodriguez   +4 more
semanticscholar   +1 more source

The Placebo and Nocebo Effect

2008
There are four general reasons for clinical improvement in a patient’s condition: (1) natural history of the disease; (2) specific effects of the treatment; (3) regression to the mean; and (4) nonspecific effects of the treatment that are attributable to factors other than the specific active components. The latter effect is included under the heading ‘
Stephen P. Glasser, William H. Frishman
openaire   +2 more sources

The role of learning in nocebo and placebo effects

Acute Pain, 2008
The nocebo effect consists in delivering verbal suggestions of negative outcomes so that the subject expects clinical worsening. Here we show that nocebo suggestions, in which expectation of pain increase is induced, are capable of producing both hyperalgesic and allodynic responses. By extending previous findings on the placebo effect, we investigated
Colloca L   +2 more
openaire   +5 more sources

Pain and the Placebo/Nocebo Effect

2011
In the last 20 years, placebo and nocebo research has provided scientific ground for a phenomenon once believed to be only patient mystification, or at best a variable to control in clinical trials. Neurochemical, pharmacological and neuroimaging studies are elucidating the mechanisms by which the activation of identifiable neural pathways produces ...
POLLO, Antonella, BENEDETTI, Fabrizio
openaire   +2 more sources

The Nocebo Effect of Informed Consent

Bioethics, 2012
ABSTRACTThe nocebo effect, the mirror‐phenomenon to the placebo effect, is when the expectation of a negative outcome precipitates the corresponding symptom or leads to its exacerbation. One of the basic ethical duties in health care is to obtain informed consent from patients before treatment; however, the disclosure of information regarding potential
openaire   +3 more sources

Ulysses Contracts and the Nocebo Effect

The American Journal of Bioethics, 2012
The nocebo effect is both recursive and detrimental. It is recursive because it is self-fulfilling; it is detrimental because the impact is either harmful or undesirable.
openaire   +3 more sources

The Power of Labeling in Nocebo Effects

2018
Nocebo effects comprise two broad types: primary nocebo effects, in which overall treatment efficacy is reduced; and nocebo side effects, which result in the increased experience of unpleasant secondary side effects. An important factor in generating nocebo effects of both types is the patient's expectations of how well a treatment will work, and how ...
Kate Faasse, Leslie R. Martin
openaire   +3 more sources

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