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2016
Placebo refers to the positive expectation that a treatment will help patients, and nocebo refers to adverse events related to patient’s negative expectations that a medical treatment will likely harm instead of healing. Both conditions illustrate the power of human brain and are strongly related to treatment outcome and adherence. Placebos and nocebos
Christina I. Deligianni +1 more
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Placebo refers to the positive expectation that a treatment will help patients, and nocebo refers to adverse events related to patient’s negative expectations that a medical treatment will likely harm instead of healing. Both conditions illustrate the power of human brain and are strongly related to treatment outcome and adherence. Placebos and nocebos
Christina I. Deligianni +1 more
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The Power of Labeling in Nocebo Effects
2018Nocebo effects comprise two broad types: primary nocebo effects, in which overall treatment efficacy is reduced; and nocebo side effects, which result in the increased experience of unpleasant secondary side effects. An important factor in generating nocebo effects of both types is the patient's expectations of how well a treatment will work, and how ...
Kate Faasse, Leslie R. Martin
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The role of learning in nocebo and placebo effects
Acute Pain, 2008The nocebo effect consists in delivering verbal suggestions of negative outcomes so that the subject expects clinical worsening. Here we show that nocebo suggestions, in which expectation of pain increase is induced, are capable of producing both hyperalgesic and allodynic responses. By extending previous findings on the placebo effect, we investigated
Colloca L +2 more
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Pain and the Placebo/Nocebo Effect
2011In the last 20 years, placebo and nocebo research has provided scientific ground for a phenomenon once believed to be only patient mystification, or at best a variable to control in clinical trials. Neurochemical, pharmacological and neuroimaging studies are elucidating the mechanisms by which the activation of identifiable neural pathways produces ...
POLLO, Antonella, BENEDETTI, Fabrizio
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Commentary: Harm, Truth, and the Nocebo Effect [PDF]
Cambridge Quarterly of Healthcare Ethics, 2020 Nocebo effects occur when an individual experiences undesirable physiological reactions caused by doxastic states that are not a treatment’s core or characteristic features.1 As Scott Gelfand2 points out, there are numerous studies that have shown that the disclosure of a treatment’s side effects to a patient increases the risk of the side effects ...
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Placebo and Nocebo Effects in Itch and Pain
2014Physical complaints, such as pain, can be effectively altered by placebo and nocebo effects due to induction of positive or negative expectations. While verbal suggestion and conditioning are recognized as playing a key role in placebo and nocebo effects on pain, these mechanisms have barely been investigated with regard to other somatosensory ...
Danielle J. P. Bartels +5 more
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The Nocebo Effect of Informed Consent
Bioethics, 2012ABSTRACTThe nocebo effect, the mirror‐phenomenon to the placebo effect, is when the expectation of a negative outcome precipitates the corresponding symptom or leads to its exacerbation. One of the basic ethical duties in health care is to obtain informed consent from patients before treatment; however, the disclosure of information regarding potential
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Visual placebo and nocebo effects
The Journal of PhysiologyAbstractPlacebo and nocebo effects modulate symptom perception through expectations and learning processes in various domains. Predominantly, their impact has been investigated on pain and physical performance. However, the influence of placebos and nocebos on visual system functionality has yet to be explored.
Piedimonte, Alessandro +6 more
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Ulysses Contracts and the Nocebo Effect
The American Journal of Bioethics, 2012The nocebo effect is both recursive and detrimental. It is recursive because it is self-fulfilling; it is detrimental because the impact is either harmful or undesirable.
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The Effects of Placebos and Nocebos on Physical Performance
2014In this chapter we present and discuss recent studies on the mechanisms underlying placebo and nocebo effects in physical performance, showing how expectations and both pharmacological and nonpharmacological preconditioning procedures can be very effective in inducing placebo responses, with important implications for sport competitions.
Carlino E., Piedimonte A., Frisaldi E.
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