Results 131 to 140 of about 2,444,013 (293)
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita +4 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.Prospectively determined clinical T and N categories clearly stratified long‐term survival in locally advanced gastric cancer. Patients with cT3N+, cT4aN0, cT4aN+, and cT4b disease showed unfavorable prognosis despite standard treatment. These findings may help optimize patient selection for perioperative treatment strategies.
Tsutomu Hayashi +19 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley +1 more source
A Unifying Approach to Self‐Organizing Systems Interacting via Conservation Laws
Advanced Intelligent Discovery, EarlyView.The article develops a unified way to model and analyze self‐organizing systems whose interactions are constrained by conservation laws. It represents physical/biological/engineered networks as graphs and builds projection operators (from incidence/cycle structure) that enforce those constraints and decompose network variables into constrained versus ...
F. Barrows +7 more
wiley +1 more source
Explaining the Origin of Negative Poisson's Ratio in Amorphous Networks With Machine Learning
Advanced Intelligent Discovery, EarlyView.This review summarizes how machine learning (ML) breaks the “vicious cycle” in designing auxetic amorphous networks. By transitioning from traditional “black‐box” optimization to an interpretable “AI‐Physics” closed‐loop paradigm, ML is shown to not only discover highly optimized structures—such as all‐convex polygon networks—but also unveil hidden ...
Shengyu Lu, Xiangying Shen
wiley +1 more source
To Greater Twist: A Kinetically Biased π‐Radical Cascade
Angewandte Chemie, EarlyView.π‐Radical cascades enable step‐economic construction of complex polycyclic aromatic frameworks. In this work, we show that a multifurcating pathway can be kinetically steered toward a single, more distorted product. This counterintuitive “falling‐upward” outcome arises from an intrinsic mechanistic bias, revealing a broader dimension of control in π ...
Yong Yang +8 more
wiley +2 more sources
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.A novel method for generating versatile standing wave fields using an acoustic metasurface deflector and retroreflector is introduced. By overcoming traditional constraints of parallel surfaces, the approach enables customizable wave patterns and enhances applications in particle manipulation.
Chadi Ellouzi +4 more
wiley +1 more source
Points in projective spaces and applications [PDF]
, 2009 We prove the factoriality of a nodal hypersurface in P4 of degree d that has at most 2(d ¡ 1)2=3 singular points, and we prove the factoriality of a double cover of P3 branched over a nodal surface of degree 2r having less than (2r ¡ 1)r singular ...
Cheltsov, Ivan
core
Advanced Intelligent Systems, EarlyView.A mechanics‐informed machine learning framework enables mechanics field prediction and inverse design of tendon–bone enthesis‐inspired functionally graded materials that reduce stress concentration and failure risk. By coupling multiscale finite element modeling, convolutional field prediction, and kernel‐based inverse design, the study uncovers ...
Zhangke Yang, Zhaoxu Meng
wiley +1 more source
Observation of Higher Order Nodal Line Semimetal in Phononic Crystals [PDF]
Higher-order topological insulators and semimetals, which generalize the conventional bulk-boundary correspondence, have attracted extensive research interest.
Ye, Liping +8 more
core +1 more source