Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. [PDF]
Glia, 2019 The fast and reliable propagation of action potentials along myelinated fibers relies on the clustering of voltage‐gated sodium channels at nodes of Ranvier. Axo‐glial communication is required for assembly of nodal proteins in the central nervous system,
Dubessy AL +16 more
europepmc +9 more sources
Production in Bacteria and Characterization of Engineered Humanized Fab Fragment against the Nodal Protein [PDF]
Pharmaceuticals, 2023 Drug development in recent years is increasingly focused on developing personalized treatments based on blocking molecules selective for therapeutic targets specifically present in individual patients.
Jwala P. Sivaccumar +7 more
doaj +6 more sources
Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis.
PLoS ONE, 2011 IntroductionYes-associated protein (YAP) is considered an oncogene found amplified in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, the role for YAP expression in HNSCC is not understood.
Lin Ge +8 more
doaj +7 more sources
Amyloid precursor protein at node of Ranvier modulates nodal formation [PDF]
Cell Adhesion & Migration, 2014 Amyloid precursor protein (APP), commonly associated with Alzheimer disease, is upregulated and distributes evenly along the injured axons, and therefore, also known as a marker of demyelinating axonal injury and axonal degeneration.
De-En Xu +9 more
semanticscholar +5 more sources
The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling [PDF]
Cell, 1999 The zebrafish EGF-CFC gene one-eyed pinhead (oep) is required zygotically for the formation of the ventral neuroectoderm, endoderm, and prechordal plate. Here we report that embryos lacking both maternal and zygotic Oep activity are defective in germ layer formation, organizer development, and the positioning of the anterior-posterior axis.
Kira Gritsman +5 more
semanticscholar +6 more sources
Bone morphogenetic protein 7 is associated with the nodal invasion of colon cancer
Oncology Letters, 2016 Environmental and genetic factors interact in the process and treatment of colon cancer, although the underlying mechanisms remain elusive. The aim of the study was to examine the role of whether bone morphogenetic protein 7 (BMP7) is involved in the ...
Tianqi Zhang +5 more
semanticscholar +6 more sources
The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesis [PDF]
Cancer Cell International, 2016 BackgroundGlioblastoma (GBM) is the most common primary brain tumor presenting self-renewing cancer stem cells. The role of these cells on the development of the tumors has been proposed to recapitulate programs from embryogenesis.
Maria Cecília Oliveira-Nunes +11 more
semanticscholar +4 more sources
Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes [PDF]
Neoplasia: An International Journal for Oncology Research, 2021 The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cells ...
Dylan Dieters-Castator +15 more
doaj +8 more sources
Supplementary Figure 1 from Embryonic Protein Nodal Promotes Breast Cancer Vascularization [PDF]
Cancer Research, 2023 Abstract Tumor vascularization is requisite for breast cancer progression, and high microvascular density in tumors is a poor prognostic indicator. Patients bearing breast cancers expressing human embryonic stem cell (hESC)-associated genes similarly exhibit high mortality rates, and the expression of embryonic proteins is associated ...
Daniela F. Quail +10 more
+7 more sources
Two Modes by which Lefty Proteins Inhibit Nodal Signaling [PDF]
Current Biology, 2004 During vertebrate embryogenesis, members of the Lefty subclass of Transforming Growth Factor-beta (TGFbeta) proteins act as extracellular antagonists of the signaling pathway for Nodal, a TGFbeta-related ligand essential for mesendoderm formation and left-right patterning.
Canhe Chen, Michael M. Shen
openalex +4 more sources